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Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation
Chen, Xuewei1; Zhang, Liwei2; Yang, Danfeng1; Li, Chao1; An, Gaihong1; Wang, Jing1; Shao, Yongcong3; Fan, Rong4; Ma, Qiang1
First AuthorChen, Xuewei
Correspondent Emailrong fan prosperity_39@sina.cn ; qiang ma maqiangw@sohu.com
2020-06-22
Source PublicationFRONTIERS IN BEHAVIORAL NEUROSCIENCE
ISSN1662-5153
Subtypearticle
Volume14Pages:12
QuartileQ2
Contribution Rank2
Abstract

Objective: Caffeine is a central nervous system stimulant that can effectively alleviate brain fatigue and low cognitive efficiency induced by total sleep deprivation (TSD). Recent studies have demonstrated that caffeine can improve subjective attention and objective behavioral metrics, such as arousal level, reaction time, and memory efficiency. However, only a few studies have examined the electrophysiological changes caused by the caffeine in humans following sleep disturbance. In this study, an event-related potential (ERP) technique was employed to measure the behavioral, cognitive, and electrophysiological changes produced by caffeine administration after TSD. Methods: Sixteen healthy subjects within-subject design performed a visual Go/No-Go task with simultaneous electroencephalogram recording. Behavioral and ERP data were evaluated after 36 h of TSD, and the effects of ingestion of either 400 mg of caffeine or placebo were compared in a double-blind randomized design. Results: Compared with placebo administration, the Go hit rates were significantly enhanced in the caffeine condition. A simple effect analysis revealed that, compared with baseline, the Go-P2 amplitude was significantly enhanced after TSD in the caffeine consumption condition. A significant main effect of the drug was found on No-Go-P2, No-Go-N2 amplitude, and Go-P2 latency before and after TSD. Conclusion: Our findings indicate that caffeine administration has acute effects on improving the efficiency of individual automatic reactions and early cognitive processes. Caffeine was related to the preservation of an individual's arousal level and accelerated response-related decisions, while subjects' higher-level recognition had limited improvement with prolonged awareness.

Keywordcaffeine ERP total sleep deprivation Go No-Go reaction time (RTs)
DOI10.3389/fnbeh.2020.00108
Indexed BySCI
Language英语
Funding OrganizationNational Military Science Foundation of China
Funding ProjectNational Military Science Foundation of China[BWS17J025] ; National Military Science Foundation of China[AWS14J011] ; National Military Science Foundation of China[AWS16J023] ; National Military Science Foundation of China[HZ18C01and Z161100002616019]
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000553792200001
PublisherFRONTIERS MEDIA SA
WOS KeywordATTENTION ; P300 ; MOOD ; TASK ; PAIN ; EEG
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32347
Collection中国科学院行为科学重点实验室
Corresponding AuthorFan, Rong; Ma, Qiang
Affiliation1.Tianjin Inst Environm & Operat Med, Dept Operat Med, Tianjin, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
3.Beijing Sport Univ, Sch Psychol, Beijing, Peoples R China
4.Xi Qing Hosp, Cent Lab, Tianjin, Peoples R China
Recommended Citation
GB/T 7714
Chen, Xuewei,Zhang, Liwei,Yang, Danfeng,et al. Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2020,14:12.
APA Chen, Xuewei.,Zhang, Liwei.,Yang, Danfeng.,Li, Chao.,An, Gaihong.,...&Ma, Qiang.(2020).Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,14,12.
MLA Chen, Xuewei,et al."Effects of Caffeine on Event-Related Potentials and Neuropsychological Indices After Sleep Deprivation".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 14(2020):12.
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