Institutional Repository of Key Laboratory of Mental Health, CAS
A dynamic mouse peptidome landscape reveals probiotic modulation of the gut-brain axis | |
Zhang, Pei1,2; Wu, Xiaoli3; Liang, Shan3,4; Shao, Xianfeng1,5; Wang, Qianqian1; Chen, Ruibing5; Zhu, Weimin1; Shao, Chen1; Jin, Feng3; Jia, Chenxi1 | |
第一作者 | Zhang, Pei |
通讯作者邮箱 | jinfeng@psych.ac.cn |
心理所单位排序 | 3 |
摘要 | Certain probiotics have beneficial effects on the function of the central nervous system through modulation of the gut-brain axis. Here, we describe a dynamic landscape of the peptidome across multiple brain regions, modulated by oral administration of different probiotic species over various times. The spatiotemporal and strain-specific changes of the brain peptidome correlated with the composition of the gut microbiome. The hippocampus exhibited the most sensitive response to probiotic treatment. The administration of heat-killed probiotics altered the hippocampus peptidome but did not substantially change the gut microbiome. We developed a literatu-remining algorithm to link the neuropeptides altered by probiotics with potential functional roles. We validated the probiotic-regulated role of corticotropin-releasing hormone by monitoring the hypothalamic-pituitary-adrenal axis, the prenatal stress-induced hyperactivity of which was attenuated by probiotics treatment. Our findings provide evidence for modulation of the brain peptidome by probiotics and provide a resource for further studies of the gut-brain axis and probiotic therapies. |
2020-07-28 | |
语种 | 英语 |
DOI | 10.1126/scisignal.abb0443 |
发表期刊 | SCIENCE SIGNALING |
ISSN | 1945-0877 |
卷号 | 13期号:642页码:14 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | National Key R&D Program of China[2017YFA0505702] ; National Key R&D Program of China[2016YFA0501302] ; National Science Foundation of China[21675006] ; Key Research Program of China[BWS17J025] ; NS Bio Japan[20170403] |
出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
WOS关键词 | ENDOGENOUS PEPTIDES ; FOOD-INTAKE ; RAT-BRAIN ; MICROBIOTA ; NEUROPEPTIDE ; DISCOVERY ; DATABASE ; IDENTIFICATION ; ABNORMALITIES ; BEHAVIORS |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
WOS记录号 | WOS:000555876300002 |
Q分类 | Q1 |
资助机构 | National Key R&D Program of China ; National Science Foundation of China ; Key Research Program of China ; NS Bio Japan |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/32397 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Shao, Chen; Jin, Feng; Jia, Chenxi |
作者单位 | 1.Beijing Inst Life, Natl Ctr Prot Sci, PHOENIX Ctr, State Key Lab Prote,Beijing Proteome Res Ctr, Beijing 102206, Peoples R China 2.Hebei Univ, Sch Life Sci, Baoding 071002, Hebei, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Inst Microbiol, Key Lab Microbial Physiol & Metab Engn, Beijing 100101, Peoples R China 5.Tianjin Med Univ, Sch Basic Med Sci, Dept Genet, Tianjin 300070, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Zhang, Pei,Wu, Xiaoli,Liang, Shan,et al. A dynamic mouse peptidome landscape reveals probiotic modulation of the gut-brain axis[J]. SCIENCE SIGNALING,2020,13(642):14. |
APA | Zhang, Pei.,Wu, Xiaoli.,Liang, Shan.,Shao, Xianfeng.,Wang, Qianqian.,...&Jia, Chenxi.(2020).A dynamic mouse peptidome landscape reveals probiotic modulation of the gut-brain axis.SCIENCE SIGNALING,13(642),14. |
MLA | Zhang, Pei,et al."A dynamic mouse peptidome landscape reveals probiotic modulation of the gut-brain axis".SCIENCE SIGNALING 13.642(2020):14. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
A dynamic mouse pept(535KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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