PSYCH OpenIR  > 中国科学院心理健康重点实验室
A dynamic mouse peptidome landscape reveals probiotic modulation of the gut-brain axis
Zhang, Pei1,2; Wu, Xiaoli3; Liang, Shan3,4; Shao, Xianfeng1,5; Wang, Qianqian1; Chen, Ruibing5; Zhu, Weimin1; Shao, Chen1; Jin, Feng3; Jia, Chenxi1
First AuthorZhang, Pei
Correspondent Emailjinfeng@psych.ac.cn
2020-07-28
Source PublicationSCIENCE SIGNALING
ISSN1945-0877
Subtypearticle
Volume13Issue:642Pages:14
QuartileQ1
Contribution Rank3
Abstract

Certain probiotics have beneficial effects on the function of the central nervous system through modulation of the gut-brain axis. Here, we describe a dynamic landscape of the peptidome across multiple brain regions, modulated by oral administration of different probiotic species over various times. The spatiotemporal and strain-specific changes of the brain peptidome correlated with the composition of the gut microbiome. The hippocampus exhibited the most sensitive response to probiotic treatment. The administration of heat-killed probiotics altered the hippocampus peptidome but did not substantially change the gut microbiome. We developed a literatu-remining algorithm to link the neuropeptides altered by probiotics with potential functional roles. We validated the probiotic-regulated role of corticotropin-releasing hormone by monitoring the hypothalamic-pituitary-adrenal axis, the prenatal stress-induced hyperactivity of which was attenuated by probiotics treatment. Our findings provide evidence for modulation of the brain peptidome by probiotics and provide a resource for further studies of the gut-brain axis and probiotic therapies.

DOI10.1126/scisignal.abb0443
Indexed BySCI
Language英语
Funding OrganizationNational Key R&D Program of China ; National Science Foundation of China ; Key Research Program of China ; NS Bio Japan
Funding ProjectNational Key R&D Program of China[2017YFA0505702] ; National Key R&D Program of China[2016YFA0501302] ; National Science Foundation of China[21675006] ; Key Research Program of China[BWS17J025] ; NS Bio Japan[20170403]
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000555876300002
PublisherAMER ASSOC ADVANCEMENT SCIENCE
WOS KeywordENDOGENOUS PEPTIDES ; FOOD-INTAKE ; RAT-BRAIN ; MICROBIOTA ; NEUROPEPTIDE ; DISCOVERY ; DATABASE ; IDENTIFICATION ; ABNORMALITIES ; BEHAVIORS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32397
Collection中国科学院心理健康重点实验室
Corresponding AuthorShao, Chen; Jin, Feng; Jia, Chenxi
Affiliation1.Beijing Inst Life, Natl Ctr Prot Sci, PHOENIX Ctr, State Key Lab Prote,Beijing Proteome Res Ctr, Beijing 102206, Peoples R China
2.Hebei Univ, Sch Life Sci, Baoding 071002, Hebei, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Inst Microbiol, Key Lab Microbial Physiol & Metab Engn, Beijing 100101, Peoples R China
5.Tianjin Med Univ, Sch Basic Med Sci, Dept Genet, Tianjin 300070, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhang, Pei,Wu, Xiaoli,Liang, Shan,et al. A dynamic mouse peptidome landscape reveals probiotic modulation of the gut-brain axis[J]. SCIENCE SIGNALING,2020,13(642):14.
APA Zhang, Pei.,Wu, Xiaoli.,Liang, Shan.,Shao, Xianfeng.,Wang, Qianqian.,...&Jia, Chenxi.(2020).A dynamic mouse peptidome landscape reveals probiotic modulation of the gut-brain axis.SCIENCE SIGNALING,13(642),14.
MLA Zhang, Pei,et al."A dynamic mouse peptidome landscape reveals probiotic modulation of the gut-brain axis".SCIENCE SIGNALING 13.642(2020):14.
Files in This Item:
File Name/Size DocType Version Access License
A dynamic mouse pept(535KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Pei]'s Articles
[Wu, Xiaoli]'s Articles
[Liang, Shan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Pei]'s Articles
[Wu, Xiaoli]'s Articles
[Liang, Shan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Pei]'s Articles
[Wu, Xiaoli]'s Articles
[Liang, Shan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.