Institutional Repository of Key Laboratory of Behavioral Science, CAS
Aging affects gain and internal noise in the visual system | |
Yan, Fang-Fang1,2; Hou, Fang3,4; Lu, Hongyu5; Yang, Jia1,2; Chen, Lijun1,2; Wu, Yifan1,2; Chen, Ge6; Huang, Chang-Bing1,2 | |
第一作者 | Yan, Fang-Fang |
通讯作者邮箱 | houf@mail.eye.ac.cn ; huangcb@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | Visual functions decline with age, but how aging degrades visual functions remains controversial. In the current study, the mechanisms underlying age-related visual declines were examined psychophysically. We developed an efficient method to quickly explore contrast sensitivity as a function of nine spatial frequencies at three levels of external noise in both young and old subjects. Fifty-two young and twenty-six old subjects have been screened for ophthalmological and mental diseases and participated in the experiment. Contrast sensitivity varied significantly with spatial frequency, age, and level of external noise. By adopting a nonlinear observer model, we decomposed contrast sensitivity into inefficiencies in internal additive noise, internal multiplicative noise, perceptual template gain, and/ or system non-linearity. Model analysis revealed that aging impacts both internal additive noise and perceptual template gain, and such age-related degradation is tuned to spatial frequency, which is also a good predictor to discriminate old from young. The quick characterization of contrast sensitivity functions at different noise levels and the accompanying analysis developed in the current study may have profound application in other clinical populations. |
2020-04-21 | |
语种 | 英语 |
DOI | 10.1038/s41598-020-63053-0 |
发表期刊 | SCIENTIFIC REPORTS |
ISSN | 2045-2322 |
卷号 | 10期号:1页码:10 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | National Key Research and Development Program of China[2018YFC0705100] ; National Natural Science Foundation of China[NSFC 31230032] ; National Natural Science Foundation of China[31470983] ; Department of Human Resources and Social Security of Zhejiang Province (Qianjiang Talent Project)[QJD1803028] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y7CX332008] ; Chinese Post-doctoral Research Foundation[2018M641514] ; Medical science and technology project of health commission of Hebei province[HYL 152777134] |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | SPATIAL CONTRAST SENSITIVITY ; EXTERNAL NOISE ; SAMPLING EFFICIENCY ; SIGNAL-DETECTION ; AGE ; OBSERVER ; DEGRADATION ; MECHANISMS ; FREQUENCY ; ATTENTION |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000559764900001 |
Q分类 | Q1 |
资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Department of Human Resources and Social Security of Zhejiang Province (Qianjiang Talent Project) ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; Chinese Post-doctoral Research Foundation ; Medical science and technology project of health commission of Hebei province |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/32409 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Hou, Fang; Huang, Chang-Bing |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Wenzhou Med Univ, Sch Ophthalmol & Optometry, Wenzhou 325027, Peoples R China 4.Wenzhou Med Univ, Eye Hosp, Wenzhou 325027, Peoples R China 5.Maternal & Child Hlth Care Hosp Qinhuangdao, Qinhuangdao 066000, Hebei, Peoples R China 6.Zhengzhou Univ Light Ind, Sch Art & Design, Zhengzhou 450000, Peoples R China |
第一作者单位 | 中国科学院行为科学重点实验室 |
通讯作者单位 | 中国科学院行为科学重点实验室 |
推荐引用方式 GB/T 7714 | Yan, Fang-Fang,Hou, Fang,Lu, Hongyu,et al. Aging affects gain and internal noise in the visual system[J]. SCIENTIFIC REPORTS,2020,10(1):10. |
APA | Yan, Fang-Fang.,Hou, Fang.,Lu, Hongyu.,Yang, Jia.,Chen, Lijun.,...&Huang, Chang-Bing.(2020).Aging affects gain and internal noise in the visual system.SCIENTIFIC REPORTS,10(1),10. |
MLA | Yan, Fang-Fang,et al."Aging affects gain and internal noise in the visual system".SCIENTIFIC REPORTS 10.1(2020):10. |
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