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Aging affects gain and internal noise in the visual system
Yan, Fang-Fang1,2; Hou, Fang3,4; Lu, Hongyu5; Yang, Jia1,2; Chen, Lijun1,2; Wu, Yifan1,2; Chen, Ge6; Huang, Chang-Bing1,2
First AuthorYan, Fang-Fang
Correspondent Emailhouf@mail.eye.ac.cn ; huangcb@psych.ac.cn
2020-04-21
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Subtypearticle
Volume10Issue:1Pages:10
QuartileQ1
Contribution Rank1
Abstract

Visual functions decline with age, but how aging degrades visual functions remains controversial. In the current study, the mechanisms underlying age-related visual declines were examined psychophysically. We developed an efficient method to quickly explore contrast sensitivity as a function of nine spatial frequencies at three levels of external noise in both young and old subjects. Fifty-two young and twenty-six old subjects have been screened for ophthalmological and mental diseases and participated in the experiment. Contrast sensitivity varied significantly with spatial frequency, age, and level of external noise. By adopting a nonlinear observer model, we decomposed contrast sensitivity into inefficiencies in internal additive noise, internal multiplicative noise, perceptual template gain, and/ or system non-linearity. Model analysis revealed that aging impacts both internal additive noise and perceptual template gain, and such age-related degradation is tuned to spatial frequency, which is also a good predictor to discriminate old from young. The quick characterization of contrast sensitivity functions at different noise levels and the accompanying analysis developed in the current study may have profound application in other clinical populations.

DOI10.1038/s41598-020-63053-0
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Department of Human Resources and Social Security of Zhejiang Province (Qianjiang Talent Project) ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; Chinese Post-doctoral Research Foundation ; Medical science and technology project of health commission of Hebei province
Funding ProjectNational Key Research and Development Program of China[2018YFC0705100] ; National Natural Science Foundation of China[NSFC 31230032] ; National Natural Science Foundation of China[31470983] ; Department of Human Resources and Social Security of Zhejiang Province (Qianjiang Talent Project)[QJD1803028] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y7CX332008] ; Chinese Post-doctoral Research Foundation[2018M641514] ; Medical science and technology project of health commission of Hebei province[HYL 152777134]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000559764900001
PublisherNATURE PUBLISHING GROUP
WOS KeywordSPATIAL CONTRAST SENSITIVITY ; EXTERNAL NOISE ; SAMPLING EFFICIENCY ; SIGNAL-DETECTION ; AGE ; OBSERVER ; DEGRADATION ; MECHANISMS ; FREQUENCY ; ATTENTION
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32409
Collection中国科学院行为科学重点实验室
Corresponding AuthorHou, Fang; Huang, Chang-Bing
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
3.Wenzhou Med Univ, Sch Ophthalmol & Optometry, Wenzhou 325027, Peoples R China
4.Wenzhou Med Univ, Eye Hosp, Wenzhou 325027, Peoples R China
5.Maternal & Child Hlth Care Hosp Qinhuangdao, Qinhuangdao 066000, Hebei, Peoples R China
6.Zhengzhou Univ Light Ind, Sch Art & Design, Zhengzhou 450000, Peoples R China
First Author AffilicationKey Laboratory of Behavioral Science, CAS
Corresponding Author AffilicationKey Laboratory of Behavioral Science, CAS
Recommended Citation
GB/T 7714
Yan, Fang-Fang,Hou, Fang,Lu, Hongyu,et al. Aging affects gain and internal noise in the visual system[J]. SCIENTIFIC REPORTS,2020,10(1):10.
APA Yan, Fang-Fang.,Hou, Fang.,Lu, Hongyu.,Yang, Jia.,Chen, Lijun.,...&Huang, Chang-Bing.(2020).Aging affects gain and internal noise in the visual system.SCIENTIFIC REPORTS,10(1),10.
MLA Yan, Fang-Fang,et al."Aging affects gain and internal noise in the visual system".SCIENTIFIC REPORTS 10.1(2020):10.
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