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Potential metabolic monitoring indicators of suicide attempts in first episode and drug naive young patients with major depressive disorder: a cross-sectional study
Zhao, Ke1; Zhou, Siyao1; Shi, Xiang1; Chen, Jianjun1; Zhang, Yaoyao1; Fan, Kaili1; Zhang, Xiangyang2,3; Wang, Wei1; Tang, Wei4,5
First AuthorZhao, Ke
Correspondent Emailtangweikn@163.com
2020-07-28
Source PublicationBMC PSYCHIATRY
ISSN1471-244X
Subtypearticle
Volume20Issue:1Pages:8
QuartileQ2
Contribution Rank2
Abstract

Backgrounds Major depressive disorder is an ordinary mental disorder, and suicide is considered to be a major concern among patients with MDD. Previous studies focused on the relationship between suicide attempts and metabolism in elderly patients with MDD, while ignore the young people. The aim of this study is to find the potential relationship between suicide attempts and metabolism in young patients with MDD to find a way to prevent and ultimately reduce suicide in young patients with MDD. Methods Cross-sectional design was employed in the study.740 patients aged between 18 and 45 years old with MDD had been consecutively recruited in this study between 2011 and 2017, 128 of whom had suicide attempts. Their serum samples used to monitor fasting blood glucose, serum lipids as well as socio-demographic characteristics were collected. Besides, some clinical scales were also employed to measure symptoms of anxiety, depression and other conditions. Results This study indicated that compared with non-suicide attempters, suicide attempters in young patients with MDD showed higher levels of FBG, TC, LDL-C (allp < 0.05) and lower levels of HDL-C(p < 0.001). Further logistic regression analysis suggested that suicide attempts were associated with increased FBG, decreased HDL-C, the course of disease, HAMD scores and obvious anxiety. Conclusions Suicide attempts in young patients with MDD may be predicted by metabolic levels in the future. And our findings suggested that the level of FBG and HDL-C can be promising biomarkers to predict the occurrence of this event.

KeywordMajor depressive disorder Suicide attempt Metabolism Biomarker
DOI10.1186/s12888-020-02791-x
Indexed BySCI
Language英语
Funding Organizationbasic scientific research project of Wenzhou ; Natural Science Foundation of Zhejiang Province ; medical and health research project of Zhejiang province
Funding Projectbasic scientific research project of Wenzhou[Y20180115] ; Natural Science Foundation of Zhejiang Province[LQ18H090009] ; medical and health research project of Zhejiang province[2020KY926]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000556820400001
PublisherBMC
WOS KeywordLOW HDL CHOLESTEROL ; NATIONAL-HEALTH ; GLUCOSE-METABOLISM ; SERUM-CHOLESTEROL ; POSITIVE SYMPTOMS ; PERCEIVED STRESS ; IDEATION ; ASSOCIATION ; ADULTS ; RISK
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32412
Collection中国科学院心理健康重点实验室
Corresponding AuthorTang, Wei
Affiliation1.Wenzhou Med Univ, Sch Mental Hlth, Wenzhou, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
4.Wenzhou Med Univ, Affiliated Kangning Hosp, Shengjin Rd, Wenzhou 325007, Zhejiang, Peoples R China
5.Wenzhou Med Univ, Wenzhou, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Ke,Zhou, Siyao,Shi, Xiang,et al. Potential metabolic monitoring indicators of suicide attempts in first episode and drug naive young patients with major depressive disorder: a cross-sectional study[J]. BMC PSYCHIATRY,2020,20(1):8.
APA Zhao, Ke.,Zhou, Siyao.,Shi, Xiang.,Chen, Jianjun.,Zhang, Yaoyao.,...&Tang, Wei.(2020).Potential metabolic monitoring indicators of suicide attempts in first episode and drug naive young patients with major depressive disorder: a cross-sectional study.BMC PSYCHIATRY,20(1),8.
MLA Zhao, Ke,et al."Potential metabolic monitoring indicators of suicide attempts in first episode and drug naive young patients with major depressive disorder: a cross-sectional study".BMC PSYCHIATRY 20.1(2020):8.
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