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Amygdala-prefrontal connectivity modulates loss aversion bias in anxious individuals
Xu, Pengfei1,2,3,4; Van Dam, Nicholas T.5; van Tol, Marie-Jose3; Shen, Xueyi6,7; Cui, Zaixu8; Gu, Ruolei9,10; Qin, Shaozheng6,7; Aleman, Andre1,3,11; Fan, Jin12; Luo, Yue-jia1,2
First AuthorPengfei Xu
Correspondent Emailjin.fan@qc.cuny.edu (j. fan) ; luoyj@szu.edu.cn (y.-j. luo).
2020-09-01
Source PublicationNEUROIMAGE
ISSN1053-8119
Subtypearticle
Volume218Pages:10
QuartileQ1
Abstract

Anxious individuals tend to make pessimistic judgments in decision making under uncertainty. While this phenomenon is commonly attributed to risk aversion, loss aversion is a critical but often overlooked factor. In this study, we simultaneously examined risk aversion and loss aversion during decision making in high and low trait anxious individuals in a variable gain/loss gambling task during functional magnetic resonance imaging. Although high relative to low anxious individuals showed significant increased risk aversive behavior reflected by decreased overall gamble decisions, there was no group difference in subjective aversion to risk. Instead, loss aversion rather than risk aversion dominantly contributed to predict behavioral decisions, which was associated with attenuated functional connectivity between the amygdala-based emotional system and the prefrontal control regions. Our findings suggest a dominant role of loss aversion in maladaptive risk assessment of anxious individuals, underpinned by disorganization of emotion-related and cognitive-control-related brain networks.

KeywordTrait anxiety Decision making Loss aversion Risk aversion Amygdala Prefrontal cortex
DOI10.1016/j.neuroimage.2020.116957
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Young Elite Scientists Sponsorship Program by China Association for Science and Technology (2018) ; Guangdong International Scientific Collaboration Project ; Guangdong Key Basic Research Grant ; Guangdong Young Innovative Talent Project ; Guangdong University Innovation Team Project ; Guangdong Basic and Applied Research Major Project ; Guangdong Pearl River Talents Plan Innovative and Entrepreneurial Team grant ; Shenzhen Science and Technology Research Program ; Shenzhen Peacock Program ; VENI grant (NWO) ; Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Fundamental Research Institutions
Funding ProjectNational Natural Science Foundation of China[31920103009] ; National Natural Science Foundation of China[31530031] ; National Natural Science Foundation of China[31871137] ; National Natural Science Foundation of China[31700959] ; National Natural Science Foundation of China[31671133] ; National Natural Science Foundation of China[31500920] ; Young Elite Scientists Sponsorship Program by China Association for Science and Technology (2018) ; Guangdong International Scientific Collaboration Project[2019A050510048] ; Guangdong Key Basic Research Grant[2018B030332001] ; Guangdong Young Innovative Talent Project[2016KQNCX149] ; Guangdong University Innovation Team Project[2015KCXTD009] ; Guangdong Basic and Applied Research Major Project[2016KZDXM009] ; Guangdong Pearl River Talents Plan Innovative and Entrepreneurial Team grant[2016ZT06S220] ; Shenzhen Science and Technology Research Program[JCYJ20180507183500566] ; Shenzhen Science and Technology Research Program[JCYJ20150729104249783] ; Shenzhen Science and Technology Research Program[JCYJ20170412164413575] ; Shenzhen Peacock Program[827000235] ; Shenzhen Peacock Program[KQTD2015033016104926] ; VENI grant (NWO)[016.156.077] ; Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Fundamental Research Institutions[2019SHIBS0003]
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000555460300003
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
WOS KeywordDECISION-MAKING ; EMOTION REGULATION ; RISK-AVERSION ; NEURAL BASIS ; ANXIETY ; DEPRESSION ; REWARD ; PROBABILITY ; DYSFUNCTION ; MECHANISMS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32418
Collection中国科学院行为科学重点实验室
Corresponding AuthorFan, Jin; Luo, Yue-jia
Affiliation1.Shenzhen Univ, Ctr Brain Disorders & Cognit Sci, Shenzhen Key Lab Affect & Social Neurosci, Shenzhen 518060, Peoples R China
2.Shenzhen Inst Neurosci, Ctr Emot & Brain, Shenzhen 518057, Peoples R China
3.Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Sci Cells & Syst, Cognit Neurosci Ctr, NL-9713 AW Groningen, Netherlands
4.Great Bay Neurosci & Technol Res Inst Hong Kong, Kwun Tong, Hong Kong, Peoples R China
5.Univ Melbourne, Sch Psychol Sci, Melbourne, Vic 3010, Australia
6.Beijing Normal Univ, Natl Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
7.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China
8.Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
9.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
10.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
11.Univ Groningen, Dept Psychol, Groningen, Netherlands
12.CUNY Queens Coll, Dept Psychol, 65-30 Kissena Blvd, Flushing, NY 11367 USA
Recommended Citation
GB/T 7714
Xu, Pengfei,Van Dam, Nicholas T.,van Tol, Marie-Jose,et al. Amygdala-prefrontal connectivity modulates loss aversion bias in anxious individuals[J]. NEUROIMAGE,2020,218:10.
APA Xu, Pengfei.,Van Dam, Nicholas T..,van Tol, Marie-Jose.,Shen, Xueyi.,Cui, Zaixu.,...&Luo, Yue-jia.(2020).Amygdala-prefrontal connectivity modulates loss aversion bias in anxious individuals.NEUROIMAGE,218,10.
MLA Xu, Pengfei,et al."Amygdala-prefrontal connectivity modulates loss aversion bias in anxious individuals".NEUROIMAGE 218(2020):10.
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