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Sex-dependent aberrant PFC development in the adolescent offspring rats exposed to variable prenatal stress
Niu, Yunxia1,2,3; Wang, Tao2; Liang, Shan4; Li, Wei2; Hu, Xu2; Wu, Xiaoli1,2; Jin, Feng2
First AuthorNiu, Yunxia
Correspondent Emailjinfeng@psych.ac.cn
2020-08-16
Source PublicationINTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
ISSN0736-5748
Subtypearticle
Pages13
Contribution Rank2
Abstract

Adolescence is a remarkable period of brain development. Prenatal stress can increase the risk of various neuropsychiatric disorders. This research investigated neurochemical and behavioural changes in the offspring rats (especially adolescences) who were treated with repeated variable prenatal stress (PNS) during the third week of gestation. The study tested the concentration of brain-derived neurotrophic factor (BDNF), cluster of differentiation 68 (CD68), synaptotagmin-1(Syt-1), 5-hydroxy-tryptamine (5-HT), dopamine (DA), glucocorticoid receptors (GRs) and oestrogen receptors (ERs) in the PFC (prefrontal cortex). We also tested prepulse inhibition (PPI) of the acoustic startle reflex (ASR) (a measure of sensorimotor gating). The main results were as follows: PNS increased the BDNF and CD68 concentrations in adolescent females, and increased the Syt-1 concentration in adolescent males. The increases in BDNF/CD68 concentration (in females) and Syt-1/DA concentration (in males) with age were disturbed by PNS, and PNS changed the sex differences in CD68 concentration in adolescence and disturbed the sex differences in the Syt-1 concentration (in adolescence) and DA concentration (in adults). In conclusion, we found that PNS lead to Sex-dependent aberrant PFC development, and might accelerate the development of the adolescent PFC, and so that lessened the age difference (between adolescence and adulthood) and the sex difference.

Keywordadolescence physiological index prefrontal cortex prepulse inhibition repeated variable prenatal stress
DOI10.1002/jdn.10034
Indexed BySCI
Language英语
Funding OrganizationNS Bio Japan
Funding ProjectNS Bio Japan
WOS Research AreaDevelopmental Biology ; Neurosciences & Neurology
WOS SubjectDevelopmental Biology ; Neurosciences
WOS IDWOS:000562890500001
PublisherWILEY
WOS KeywordMEDIAL PREFRONTAL CORTEX ; NEUROTROPHIC FACTOR ; PREPULSE INHIBITION ; STARTLE REFLEX ; MESSENGER-RNA ; BRAIN ; SCHIZOPHRENIA ; PLASTICITY ; INCREASES ; ANXIETY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32483
Collection中国科学院心理健康重点实验室
Corresponding AuthorJin, Feng
Affiliation1.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Tianjin Univ Technol & Educ, Sch Vocat Educ, Tianjin, Peoples R China
4.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Microbial Physiol & Metab Engn, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Niu, Yunxia,Wang, Tao,Liang, Shan,et al. Sex-dependent aberrant PFC development in the adolescent offspring rats exposed to variable prenatal stress[J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,2020:13.
APA Niu, Yunxia.,Wang, Tao.,Liang, Shan.,Li, Wei.,Hu, Xu.,...&Jin, Feng.(2020).Sex-dependent aberrant PFC development in the adolescent offspring rats exposed to variable prenatal stress.INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,13.
MLA Niu, Yunxia,et al."Sex-dependent aberrant PFC development in the adolescent offspring rats exposed to variable prenatal stress".INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2020):13.
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