Institutional Repository of Key Laboratory of Mental Health, CAS
MTHFR Ala222Val polymorphism and clinical characteristics confer susceptibility to suicide attempt in chronic patients with schizophrenia | |
Liu, Jia Hong1; Zhu, Cheng1; Zheng, Ke1; Tang, Wei1; Gao, Li Li1; Trihn, Tammy H.1; Wu, Hanjing Emily2; Chen, Chun3; Xiu, Mei Hong3; Zhang, Xiang Yang4 | |
第一作者 | Liu, Jia Hong |
通讯作者邮箱 | xiumeihong97@163.com ; zhangxy@psych.ac.cn |
心理所单位排序 | 4 |
摘要 | Patients with schizophrenia (SCZ) exhibit higher suicide rates than the general population. However, the molecular mechanism responsible for the high rate of suicidal behavior in SCZ remains poorly understood. MTHFR Ala222Val (C677T; rs 1801133) polymorphism has repeatedly demonstrated to play a pathological role in numerous mental disorders, but none of these studies focused on the susceptibility of suicidal behavior in SCZ. In the present cross-sectional study, we recruited 957 chronic inpatients with SCZ and 576 healthy controls to assess the psychopathological symptoms of SCZ and compare the frequency of the MTHFR Ala222Val genotype in both suicide attempters and non-attempters. Our results demonstrated no significant differences in MTHFR Ala222Val genotype and allele distributions between the SCZ patients and controls (p > 0.05), but showed a statistical significance in the distribution of Ala/Val genotype between suicide attempters and non-attempters (p < 0.05). Further logistic regression analysis showed that MTHFR Ala222Val genotype, psychopathological symptoms, number of cigarettes smoked per day and drinking status were related to suicide attempts in SCZ (p < 0.05). Our study demonstrated that MTHFR Ala222Val polymorphism and some clinical characteristics might confer susceptibility to suicide in patients with SCZ. |
2020-03-19 | |
语种 | 英语 |
DOI | 10.1038/s41598-020-57411-1 |
发表期刊 | SCIENTIFIC REPORTS |
ISSN | 2045-2322 |
卷号 | 10期号:1页码:9 |
期刊论文类型 | article |
收录类别 | SCI |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | METHYLENETETRAHYDROFOLATE-REDUCTASE GENE ; NEGATIVE SYNDROME SCALE ; C677T POLYMORPHISM ; BIPOLAR-DISORDER ; PLASMA HOMOCYSTEINE ; PREFRONTAL CORTEX ; WIDE ASSOCIATION ; NO ASSOCIATION ; POPULATION ; FOLATE |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000563440800008 |
Q分类 | Q1 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/32506 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Xiu, Mei Hong; Zhang, Xiang Yang |
作者单位 | 1.Wenzhou Kangning Hosp, Wenzhou, Peoples R China 2.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 3.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Liu, Jia Hong,Zhu, Cheng,Zheng, Ke,et al. MTHFR Ala222Val polymorphism and clinical characteristics confer susceptibility to suicide attempt in chronic patients with schizophrenia[J]. SCIENTIFIC REPORTS,2020,10(1):9. |
APA | Liu, Jia Hong.,Zhu, Cheng.,Zheng, Ke.,Tang, Wei.,Gao, Li Li.,...&Zhang, Xiang Yang.(2020).MTHFR Ala222Val polymorphism and clinical characteristics confer susceptibility to suicide attempt in chronic patients with schizophrenia.SCIENTIFIC REPORTS,10(1),9. |
MLA | Liu, Jia Hong,et al."MTHFR Ala222Val polymorphism and clinical characteristics confer susceptibility to suicide attempt in chronic patients with schizophrenia".SCIENTIFIC REPORTS 10.1(2020):9. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
MTHFR Ala222Val poly(1132KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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