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MTHFR Ala222Val polymorphism and clinical characteristics confer susceptibility to suicide attempt in chronic patients with schizophrenia
Liu, Jia Hong1; Zhu, Cheng1; Zheng, Ke1; Tang, Wei1; Gao, Li Li1; Trihn, Tammy H.1; Wu, Hanjing Emily2; Chen, Chun3; Xiu, Mei Hong3; Zhang, Xiang Yang4
First AuthorLiu, Jia Hong
Correspondent Emailxiumeihong97@163.com ; zhangxy@psych.ac.cn
Contribution Rank4
Abstract

Patients with schizophrenia (SCZ) exhibit higher suicide rates than the general population. However, the molecular mechanism responsible for the high rate of suicidal behavior in SCZ remains poorly understood. MTHFR Ala222Val (C677T; rs 1801133) polymorphism has repeatedly demonstrated to play a pathological role in numerous mental disorders, but none of these studies focused on the susceptibility of suicidal behavior in SCZ. In the present cross-sectional study, we recruited 957 chronic inpatients with SCZ and 576 healthy controls to assess the psychopathological symptoms of SCZ and compare the frequency of the MTHFR Ala222Val genotype in both suicide attempters and non-attempters. Our results demonstrated no significant differences in MTHFR Ala222Val genotype and allele distributions between the SCZ patients and controls (p > 0.05), but showed a statistical significance in the distribution of Ala/Val genotype between suicide attempters and non-attempters (p < 0.05). Further logistic regression analysis showed that MTHFR Ala222Val genotype, psychopathological symptoms, number of cigarettes smoked per day and drinking status were related to suicide attempts in SCZ (p < 0.05). Our study demonstrated that MTHFR Ala222Val polymorphism and some clinical characteristics might confer susceptibility to suicide in patients with SCZ.

2020-03-19
Language英语
DOI10.1038/s41598-020-57411-1
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume10Issue:1Pages:9
Subtypearticle
Indexed BySCI
PublisherNATURE PUBLISHING GROUP
WOS KeywordMETHYLENETETRAHYDROFOLATE-REDUCTASE GENE ; NEGATIVE SYNDROME SCALE ; C677T POLYMORPHISM ; BIPOLAR-DISORDER ; PLASMA HOMOCYSTEINE ; PREFRONTAL CORTEX ; WIDE ASSOCIATION ; NO ASSOCIATION ; POPULATION ; FOLATE
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000563440800008
QuartileQ1
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32506
Collection中国科学院心理健康重点实验室
Corresponding AuthorXiu, Mei Hong; Zhang, Xiang Yang
Affiliation1.Wenzhou Kangning Hosp, Wenzhou, Peoples R China
2.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
3.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Liu, Jia Hong,Zhu, Cheng,Zheng, Ke,et al. MTHFR Ala222Val polymorphism and clinical characteristics confer susceptibility to suicide attempt in chronic patients with schizophrenia[J]. SCIENTIFIC REPORTS,2020,10(1):9.
APA Liu, Jia Hong.,Zhu, Cheng.,Zheng, Ke.,Tang, Wei.,Gao, Li Li.,...&Zhang, Xiang Yang.(2020).MTHFR Ala222Val polymorphism and clinical characteristics confer susceptibility to suicide attempt in chronic patients with schizophrenia.SCIENTIFIC REPORTS,10(1),9.
MLA Liu, Jia Hong,et al."MTHFR Ala222Val polymorphism and clinical characteristics confer susceptibility to suicide attempt in chronic patients with schizophrenia".SCIENTIFIC REPORTS 10.1(2020):9.
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