Institutional Repository of Key Laboratory of Mental Health, CAS
Study of B Cell Repertoire in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis | |
Feng, Jingjing1,2; Fan, Siyuan3; Sun, Yinwei1,2; Zhang, Zhidong4; Ren, Haitao3; Li, Wenhan4; Cui, Liying3; Peng, Bin3; Ren, Xiaotun5; Zhang, Weihua5; Guan, Hongzhi3; Wang, Jing1,2 | |
第一作者 | Feng, Jingjing |
通讯作者邮箱 | hongzhi guan guanhz@263.net ; jing wang wangjing@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common antibody-mediated encephalitis. There are several studies on B cell repertoire of anti-NMDAR encephalitis in Caucasians. Here, the cerebrospinal fluid (CSF) samples of 12 Chinese patients with first-episode anti-NMDAR encephalitis were collected to investigate the B cell receptor (BCR) binding to NMDAR by single cell amplification of BCR and Sanger sequencing. BCR data of healthy persons, and of patients with anti-leucine-rich glioma inactivated 1 (anti-LGI1) encephalitis, multiple sclerosis (MS), and neuromyelitis optica spectrum disorder (NMOSD) from the public databases were used as control. A heavy chain common clone IGHV1-18*04,IGHD1-26*01/ IGHD2-2*03/IGHD2-8*01, IGHJ3*02_(CDR3) ARVGSKYGFETFDI was found in 11 of 12 enrolled patients but not in the comparison data set. In addition, 4 shared clonotypes were found among these patients, and three of them contained the common clone. This study also revealed that the antibody gene family usage preference between patients and healthy controls were different, while they had similar antibody mutation rate. Our findings may have potential clinical implications for the diagnosis of anti-NMDAR encephalitis. |
关键词 | anti-NMDAR encephalitis B cell repertoire single cell common clone diagnosis |
2020-07-29 | |
语种 | 英语 |
DOI | 10.3389/fimmu.2020.01539 |
发表期刊 | FRONTIERS IN IMMUNOLOGY |
ISSN | 1664-3224 |
卷号 | 11页码:10 |
期刊论文类型 | article |
收录类别 | SCI |
资助项目 | CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; National Key Research and Development Program of China[2016YFC0901500] |
出版者 | FRONTIERS MEDIA SA |
WOS关键词 | ANTIBODIES ; DIAGNOSIS |
WOS研究方向 | Immunology |
WOS类目 | Immunology |
WOS记录号 | WOS:000561450600001 |
Q分类 | Q1 |
资助机构 | CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; National Key Research and Development Program of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/32524 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Guan, Hongzhi; Wang, Jing |
作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China 4.Oumeng V Med Lab, Hangzhou, Peoples R China 5.Capital Med Univ, Natl Ctr Childrens Hlth, Dept Neurol, Beijing Childrens Hosp, Beijing, Peoples R China |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Feng, Jingjing,Fan, Siyuan,Sun, Yinwei,et al. Study of B Cell Repertoire in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis[J]. FRONTIERS IN IMMUNOLOGY,2020,11:10. |
APA | Feng, Jingjing.,Fan, Siyuan.,Sun, Yinwei.,Zhang, Zhidong.,Ren, Haitao.,...&Wang, Jing.(2020).Study of B Cell Repertoire in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis.FRONTIERS IN IMMUNOLOGY,11,10. |
MLA | Feng, Jingjing,et al."Study of B Cell Repertoire in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis".FRONTIERS IN IMMUNOLOGY 11(2020):10. |
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