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Study of B Cell Repertoire in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Feng, Jingjing1,2; Fan, Siyuan3; Sun, Yinwei1,2; Zhang, Zhidong4; Ren, Haitao3; Li, Wenhan4; Cui, Liying3; Peng, Bin3; Ren, Xiaotun5; Zhang, Weihua5; Guan, Hongzhi3; Wang, Jing1,2
First AuthorFeng, Jingjing
Correspondent Emailhongzhi guan guanhz@263.net ; jing wang wangjing@psych.ac.cn
2020-07-29
Source PublicationFRONTIERS IN IMMUNOLOGY
ISSN1664-3224
Subtypearticle
Volume11Pages:10
QuartileQ1
Contribution Rank1
Abstract

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common antibody-mediated encephalitis. There are several studies on B cell repertoire of anti-NMDAR encephalitis in Caucasians. Here, the cerebrospinal fluid (CSF) samples of 12 Chinese patients with first-episode anti-NMDAR encephalitis were collected to investigate the B cell receptor (BCR) binding to NMDAR by single cell amplification of BCR and Sanger sequencing. BCR data of healthy persons, and of patients with anti-leucine-rich glioma inactivated 1 (anti-LGI1) encephalitis, multiple sclerosis (MS), and neuromyelitis optica spectrum disorder (NMOSD) from the public databases were used as control. A heavy chain common clone IGHV1-18*04,IGHD1-26*01/ IGHD2-2*03/IGHD2-8*01, IGHJ3*02_(CDR3) ARVGSKYGFETFDI was found in 11 of 12 enrolled patients but not in the comparison data set. In addition, 4 shared clonotypes were found among these patients, and three of them contained the common clone. This study also revealed that the antibody gene family usage preference between patients and healthy controls were different, while they had similar antibody mutation rate. Our findings may have potential clinical implications for the diagnosis of anti-NMDAR encephalitis.

Keywordanti-NMDAR encephalitis B cell repertoire single cell common clone diagnosis
DOI10.3389/fimmu.2020.01539
Indexed BySCI
Language英语
Funding OrganizationCAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; National Key Research and Development Program of China
Funding ProjectCAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; National Key Research and Development Program of China[2016YFC0901500]
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000561450600001
PublisherFRONTIERS MEDIA SA
WOS KeywordANTIBODIES ; DIAGNOSIS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32524
Collection中国科学院心理健康重点实验室
Corresponding AuthorGuan, Hongzhi; Wang, Jing
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China
4.Oumeng V Med Lab, Hangzhou, Peoples R China
5.Capital Med Univ, Natl Ctr Childrens Hlth, Dept Neurol, Beijing Childrens Hosp, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Feng, Jingjing,Fan, Siyuan,Sun, Yinwei,et al. Study of B Cell Repertoire in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis[J]. FRONTIERS IN IMMUNOLOGY,2020,11:10.
APA Feng, Jingjing.,Fan, Siyuan.,Sun, Yinwei.,Zhang, Zhidong.,Ren, Haitao.,...&Wang, Jing.(2020).Study of B Cell Repertoire in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis.FRONTIERS IN IMMUNOLOGY,11,10.
MLA Feng, Jingjing,et al."Study of B Cell Repertoire in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis".FRONTIERS IN IMMUNOLOGY 11(2020):10.
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