健康与遗传心理学研究室知识库

Background: Patients with schizophrenia are at a higher risk for suicide compared with the general population. Dopamine beta-hydroxylase (D beta H) plays a key role in the conversion of dopamine to norepinephrine, which is related to suicidal behavior and cognitive regulation. Objective: To examine whether there is the effect ofD beta H5 '-insertion/deletion (Ins/Del) polymorphism on cognitive performance in suicide attempters with chronic schizophrenia. Methods This polymorphism was detected in 114 suicide attempters and 617 non-suicide attempters with chronic schizophrenia. Cognitive performance was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Results: The allelic and genotypic frequencies of this polymorphism between two groups did not differ after controlling for covariates (both,p> .05). There were no differences in RBANS scores between two groups after adjusting for covariates (all,p> .05). However, based on the genotype grouping in suicide attempters and non-attempters, the attention score significantly differed after adjusting for covariates (both,p< .05). Further analysis indicated that this polymorphism was associated with attention score in suicide attempters (p< .05), but not in non-suicide attempters (p> .05). Conclusions: D beta H5 '-Ins/Del polymorphism was not a risk locus of suicide attempters, but it was implicated in attention regulation in suicide attempters with chronic schizophrenia.

Suzhou Municipal Sci-Tech Bureau Program;Suzhou Municipal Health Commission Science Research Program;CAS Key Laboratory of Mental Health, Institute of Psychology;Jiangsu Six Talent Peaks Project;National Natural Science Foundation of China;Jiangsu Provincial Health Commission Science Research Program;Jiangsu Key Research and Development Program