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Association between dopamine beta-hydroxylase polymorphism and attention function in suicide attempters with chronic schizophrenia
Hui, Li1; Hu, Wei Ming2; Zhu, Zhen Hua1; Gao, Song Tian3; Han, Mei4; Fan, Yu1; Tian, Qing1; Yin, Xu Yuan1; Yuan, Ying1; Jiang, Cai Xia1; Yin, Guang Zhong1; Jia, Qiu Fang1; Zhang, Xiang Yang1,5
Corresponding AuthorHui, Li(huili004100@126.com) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn)
2020-09-08
Source PublicationHUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
ISSN0885-6222
Pages8
AbstractBackground: Patients with schizophrenia are at a higher risk for suicide compared with the general population. Dopamine beta-hydroxylase (D beta H) plays a key role in the conversion of dopamine to norepinephrine, which is related to suicidal behavior and cognitive regulation. Objective: To examine whether there is the effect ofD beta H5 '-insertion/deletion (Ins/Del) polymorphism on cognitive performance in suicide attempters with chronic schizophrenia. Methods This polymorphism was detected in 114 suicide attempters and 617 non-suicide attempters with chronic schizophrenia. Cognitive performance was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Results: The allelic and genotypic frequencies of this polymorphism between two groups did not differ after controlling for covariates (both,p> .05). There were no differences in RBANS scores between two groups after adjusting for covariates (all,p> .05). However, based on the genotype grouping in suicide attempters and non-attempters, the attention score significantly differed after adjusting for covariates (both,p< .05). Further analysis indicated that this polymorphism was associated with attention score in suicide attempters (p< .05), but not in non-suicide attempters (p> .05). Conclusions: D beta H5 '-Ins/Del polymorphism was not a risk locus of suicide attempters, but it was implicated in attention regulation in suicide attempters with chronic schizophrenia.
Keywordattention D beta H polymorphism schizophrenia suicide attempters
DOI10.1002/hup.2755
Indexed BySCI
Language英语
Funding OrganizationSuzhou Municipal Sci-Tech Bureau Program ; Suzhou Municipal Health Commission Science Research Program ; CAS Key Laboratory of Mental Health, Institute of Psychology ; Jiangsu Six Talent Peaks Project ; National Natural Science Foundation of China ; Jiangsu Provincial Health Commission Science Research Program ; Jiangsu Key Research and Development Program
Funding ProjectSuzhou Municipal Sci-Tech Bureau Program[SYS2019113] ; Suzhou Municipal Sci-Tech Bureau Program[SZS201722] ; Suzhou Municipal Sci-Tech Bureau Program[SS201706] ; Suzhou Municipal Sci-Tech Bureau Program[SS2019009] ; Suzhou Municipal Health Commission Science Research Program[SZYJTD201715] ; Suzhou Municipal Health Commission Science Research Program[LCZX201820] ; Suzhou Municipal Health Commission Science Research Program[Kjxw2018048] ; Suzhou Municipal Health Commission Science Research Program[Gwzx2018] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2019K03] ; Jiangsu Six Talent Peaks Project[WSN-165] ; National Natural Science Foundation of China[81771439] ; Jiangsu Provincial Health Commission Science Research Program[QNRC2016228] ; Jiangsu Provincial Health Commission Science Research Program[H2019056] ; Jiangsu Provincial Health Commission Science Research Program[LGY2018010] ; Jiangsu Key Research and Development Program[BE2020661] ; Jiangsu Key Research and Development Program[BE2018662]
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS SubjectClinical Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS IDWOS:000566739400001
PublisherWILEY
WOS KeywordBP INSERTION/DELETION POLYMORPHISM ; COGNITIVE FUNCTION ; ELDERLY-WOMEN ; GENE ; RISK ; DBH ; DEPRESSION ; NOREPINEPHRINE ; 1ST-EPISODE ; PERFORMANCE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32609
Collection健康与遗传心理学研究室
Corresponding AuthorHui, Li; Zhang, Xiang Yang
Affiliation1.Soochow Univ, Affiliated Guangji Hosp, Res Ctr Biol Psychiat, 11 Guangqian Rd, Suzhou 215137, Peoples R China
2.Mental Hlth Ctr Yanqing Dist, Beijing, Peoples R China
3.Xinghua Forth Peoples Hosp, Xinghua, Peoples R China
4.Univ Wollongong, Sch Med, Wollongong, NSW, Australia
5.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
Corresponding Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Hui, Li,Hu, Wei Ming,Zhu, Zhen Hua,et al. Association between dopamine beta-hydroxylase polymorphism and attention function in suicide attempters with chronic schizophrenia[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,2020:8.
APA Hui, Li.,Hu, Wei Ming.,Zhu, Zhen Hua.,Gao, Song Tian.,Han, Mei.,...&Zhang, Xiang Yang.(2020).Association between dopamine beta-hydroxylase polymorphism and attention function in suicide attempters with chronic schizophrenia.HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,8.
MLA Hui, Li,et al."Association between dopamine beta-hydroxylase polymorphism and attention function in suicide attempters with chronic schizophrenia".HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2020):8.
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