Institutional Repository of Key Laboratory of Behavioral Science, CAS
Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder | |
Wang, Xiaoming1,2; Cui, Shaojuan3; Wu, Michael Shengtao4; Wang, Yun5,6; Gao, Qinglin1,2; Zhou, Yuan1,2,5,6 | |
第一作者 | Wang, Xiaoming |
通讯作者邮箱 | zhouyuan@psych.ac.cn (yuan zhou ) |
心理所单位排序 | 1 |
摘要 | Background Dysfunctional beliefs about the self are common in the development of depressive symptoms, but it remains unclear how depressed patients respond to unfair treatment, both dispositionally and neurally. The present research is an attempt to explore the differences in sensitivity to injustice as a victim and its neural correlates in patients with major depressive disorder (MDD) versus healthy controls. Methods First episodic, drug-naive patients with MDD (n= 30) and a control group (n= 30) were recruited to compare their differences in victim sensitivity. A second group of patients with MDD (n= 23) and their controls (n= 28) were recruited to replicate the findings and completed resting-state functional magnetic resonance imaging (fMRI) scanning. Spontaneous brain activity measured by fractional amplitude of low-frequency fluctuation (fALFF) was used to characterize the neural correlates of victim sensitivity both in patients and in healthy controls. Results Higher victim sensitivity was consistently found in patients with MDD than healthy controls in both datasets. Multiple regression analysis on the fALFF showed a significant interaction effect between diagnosis and victim sensitivity in the right dorsolateral prefrontal cortex (DLPFC). Conclusions The patients with MDD show higher sensitivity to injustice as a victim, which may be independent of their disease course. The MDD patients differ from healthy controls in the neural correlates of victim sensitivity. These findings shed light on the linkage between cognitive control subserved by the DLPFC and negative bias towards the self implicated by higher victim sensitivity among the depressed patients. |
关键词 | victim sensitivity major depressive disorder dorsolateral prefrontal cortex fractional amplitude of low-frequency fluctuation resting-state fMRI |
2020-08-11 | |
语种 | 英语 |
DOI | 10.3389/fpsyt.2020.00622 |
发表期刊 | FRONTIERS IN PSYCHIATRY |
ISSN | 1664-0640 |
卷号 | 11页码:9 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | Natural Science Foundation of China[81771473] ; State High-Tech Development Plan of China (863)[2015AA020513] |
出版者 | FRONTIERS MEDIA SA |
WOS关键词 | COGNITIVE-CONTROL ; JUSTICE SENSITIVITY ; FUNCTIONAL CONNECTIVITY ; DECISION-MAKING ; ULTIMATUM GAME ; RESTING STATE ; BRAIN ; FMRI ; METAANALYSIS ; ASSOCIATION |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000565650600001 |
资助机构 | Natural Science Foundation of China ; State High-Tech Development Plan of China (863) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/32621 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Zhou, Yuan |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Capital Med Univ, Beijing Tongren Hosp, Dept Psychol, Beijing, Peoples R China 4.Xiamen Univ, Sch Sociol & Anthropol, Xiamen, Peoples R China 5.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 6.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China |
第一作者单位 | 中国科学院行为科学重点实验室 |
通讯作者单位 | 中国科学院行为科学重点实验室 |
推荐引用方式 GB/T 7714 | Wang, Xiaoming,Cui, Shaojuan,Wu, Michael Shengtao,et al. Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder[J]. FRONTIERS IN PSYCHIATRY,2020,11:9. |
APA | Wang, Xiaoming,Cui, Shaojuan,Wu, Michael Shengtao,Wang, Yun,Gao, Qinglin,&Zhou, Yuan.(2020).Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder.FRONTIERS IN PSYCHIATRY,11,9. |
MLA | Wang, Xiaoming,et al."Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder".FRONTIERS IN PSYCHIATRY 11(2020):9. |
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