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Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder
Wang, Xiaoming1,2; Cui, Shaojuan3; Wu, Michael Shengtao4; Wang, Yun5,6; Gao, Qinglin1,2; Zhou, Yuan1,2,5,6
第一作者Wang, Xiaoming
通讯作者邮箱zhouyuan@psych.ac.cn (yuan zhou )
心理所单位排序1
摘要

Background Dysfunctional beliefs about the self are common in the development of depressive symptoms, but it remains unclear how depressed patients respond to unfair treatment, both dispositionally and neurally. The present research is an attempt to explore the differences in sensitivity to injustice as a victim and its neural correlates in patients with major depressive disorder (MDD) versus healthy controls. Methods First episodic, drug-naive patients with MDD (n= 30) and a control group (n= 30) were recruited to compare their differences in victim sensitivity. A second group of patients with MDD (n= 23) and their controls (n= 28) were recruited to replicate the findings and completed resting-state functional magnetic resonance imaging (fMRI) scanning. Spontaneous brain activity measured by fractional amplitude of low-frequency fluctuation (fALFF) was used to characterize the neural correlates of victim sensitivity both in patients and in healthy controls. Results Higher victim sensitivity was consistently found in patients with MDD than healthy controls in both datasets. Multiple regression analysis on the fALFF showed a significant interaction effect between diagnosis and victim sensitivity in the right dorsolateral prefrontal cortex (DLPFC). Conclusions The patients with MDD show higher sensitivity to injustice as a victim, which may be independent of their disease course. The MDD patients differ from healthy controls in the neural correlates of victim sensitivity. These findings shed light on the linkage between cognitive control subserved by the DLPFC and negative bias towards the self implicated by higher victim sensitivity among the depressed patients.

关键词victim sensitivity major depressive disorder dorsolateral prefrontal cortex fractional amplitude of low-frequency fluctuation resting-state fMRI
2020-08-11
语种英语
DOI10.3389/fpsyt.2020.00622
发表期刊FRONTIERS IN PSYCHIATRY
ISSN1664-0640
卷号11页码:9
期刊论文类型实证研究
收录类别SCI
资助项目Natural Science Foundation of China[81771473] ; State High-Tech Development Plan of China (863)[2015AA020513]
出版者FRONTIERS MEDIA SA
WOS关键词COGNITIVE-CONTROL ; JUSTICE SENSITIVITY ; FUNCTIONAL CONNECTIVITY ; DECISION-MAKING ; ULTIMATUM GAME ; RESTING STATE ; BRAIN ; FMRI ; METAANALYSIS ; ASSOCIATION
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000565650600001
资助机构Natural Science Foundation of China ; State High-Tech Development Plan of China (863)
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/32621
专题中国科学院行为科学重点实验室
通讯作者Zhou, Yuan
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Capital Med Univ, Beijing Tongren Hosp, Dept Psychol, Beijing, Peoples R China
4.Xiamen Univ, Sch Sociol & Anthropol, Xiamen, Peoples R China
5.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
6.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China
第一作者单位中国科学院行为科学重点实验室
通讯作者单位中国科学院行为科学重点实验室
推荐引用方式
GB/T 7714
Wang, Xiaoming,Cui, Shaojuan,Wu, Michael Shengtao,et al. Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder[J]. FRONTIERS IN PSYCHIATRY,2020,11:9.
APA Wang, Xiaoming,Cui, Shaojuan,Wu, Michael Shengtao,Wang, Yun,Gao, Qinglin,&Zhou, Yuan.(2020).Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder.FRONTIERS IN PSYCHIATRY,11,9.
MLA Wang, Xiaoming,et al."Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder".FRONTIERS IN PSYCHIATRY 11(2020):9.
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