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Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder
Wang, Xiaoming1,2; Cui, Shaojuan3; Wu, Michael Shengtao4; Wang, Yun5,6; Gao, Qinglin1,2; Zhou, Yuan1,2,5,6
Corresponding AuthorZhou, Yuan(zhouyuan@psych.ac.cn)
2020-08-11
Source PublicationFRONTIERS IN PSYCHIATRY
ISSN1664-0640
Volume11Pages:9
AbstractBackground Dysfunctional beliefs about the self are common in the development of depressive symptoms, but it remains unclear how depressed patients respond to unfair treatment, both dispositionally and neurally. The present research is an attempt to explore the differences in sensitivity to injustice as a victim and its neural correlates in patients with major depressive disorder (MDD) versus healthy controls. Methods First episodic, drug-naive patients with MDD (n= 30) and a control group (n= 30) were recruited to compare their differences in victim sensitivity. A second group of patients with MDD (n= 23) and their controls (n= 28) were recruited to replicate the findings and completed resting-state functional magnetic resonance imaging (fMRI) scanning. Spontaneous brain activity measured by fractional amplitude of low-frequency fluctuation (fALFF) was used to characterize the neural correlates of victim sensitivity both in patients and in healthy controls. Results Higher victim sensitivity was consistently found in patients with MDD than healthy controls in both datasets. Multiple regression analysis on the fALFF showed a significant interaction effect between diagnosis and victim sensitivity in the right dorsolateral prefrontal cortex (DLPFC). Conclusions The patients with MDD show higher sensitivity to injustice as a victim, which may be independent of their disease course. The MDD patients differ from healthy controls in the neural correlates of victim sensitivity. These findings shed light on the linkage between cognitive control subserved by the DLPFC and negative bias towards the self implicated by higher victim sensitivity among the depressed patients.
Keywordvictim sensitivity major depressive disorder dorsolateral prefrontal cortex fractional amplitude of low-frequency fluctuation resting-state fMRI
DOI10.3389/fpsyt.2020.00622
Indexed BySCI
Language英语
Funding OrganizationNatural Science Foundation of China ; State High-Tech Development Plan of China (863)
Funding ProjectNatural Science Foundation of China[81771473] ; State High-Tech Development Plan of China (863)[2015AA020513]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000565650600001
PublisherFRONTIERS MEDIA SA
WOS KeywordCOGNITIVE-CONTROL ; JUSTICE SENSITIVITY ; FUNCTIONAL CONNECTIVITY ; DECISION-MAKING ; ULTIMATUM GAME ; RESTING STATE ; BRAIN ; FMRI ; METAANALYSIS ; ASSOCIATION
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32621
Collection中国科学院行为科学重点实验室
Corresponding AuthorZhou, Yuan
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Capital Med Univ, Beijing Tongren Hosp, Dept Psychol, Beijing, Peoples R China
4.Xiamen Univ, Sch Sociol & Anthropol, Xiamen, Peoples R China
5.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
6.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Behavioral Science, CAS
Corresponding Author AffilicationKey Laboratory of Behavioral Science, CAS
Recommended Citation
GB/T 7714
Wang, Xiaoming,Cui, Shaojuan,Wu, Michael Shengtao,et al. Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder[J]. FRONTIERS IN PSYCHIATRY,2020,11:9.
APA Wang, Xiaoming,Cui, Shaojuan,Wu, Michael Shengtao,Wang, Yun,Gao, Qinglin,&Zhou, Yuan.(2020).Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder.FRONTIERS IN PSYCHIATRY,11,9.
MLA Wang, Xiaoming,et al."Victim Sensitivity and Its Neural Correlates Among Patients With Major Depressive Disorder".FRONTIERS IN PSYCHIATRY 11(2020):9.
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