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Burnout in university faculty: An interaction between subjective sleep quality and the OXTR rs2268498 polymorphism
Wu, Jiao1,2; Dong, Yan3; Zhao, Xue-rong1,2; He, Shu-chang1,2; Zhang, Xiang-Yang4
First AuthorWu, Jiao
Correspondent Emailshuchangh@pku.edu.cn (s.-c. he) ; zhangxy@psych.ac.cn (x.-y. zhang)
2020-11-01
Source PublicationJOURNAL OF AFFECTIVE DISORDERS
ISSN0165-0327
Subtypearticle
Volume276Pages:927-935
Contribution Rank4
Abstract

Background: Job burnout is a stress-related syndrome influenced by both genetic and environmental factors. Poor sleep quality acting as a stressor may lead to job burnout. The oxytocin receptor gene (OXTR) related to stress reactivity may also exert an effect on job burnout. We aimed to explore the effect of sleep quality, a functional OXTR rs2268498 polymorphism, and their interaction on job burnout in the Chinese population, which has not been explored yet. Methods: A preliminary study was performed using a cross-sectional design. The Pittsburgh Sleep Quality Index (PSQI) and the Malash Burnout Inventory (MBI) were measured from 575 healthy subjects. The OXTR rs2468498 polymorphism was genotyped in 376 subjects. Results: There were significant main effects of sleep quality (p<0.05), but not of the OXTR rs2468498 genotype on burnout. Interestingly, the interaction between sleep quality and the rs2468498 genotype was significant (p<0.05). In the poor sleep group, the C allele (C/C and T/C) carriers showed higher Emotional Exhaustion level than T homozygotes, while in the good sleep group, the C allele carrier showed a lower Emotional Exhaustion level. Limitations: This study covered subjects from only one university and the sample size for genotyping was relatively small. As we analyzed only the OXTR rs2268498 polymorphism, this study could not reveal the effects of the cerebrospinal oxytocin concentration and the haplotypes. Conclusions: Our findings suggest that the OXTR polymorphism modulates the influence of subjective sleep quality on burnout. We conclude that the C allele of the OXTR rs2468498 polymorphism plays a susceptible role in job burnout.

KeywordJob burnout Sleep quality OXTR polymorphism rs2268498 University faculty
DOI10.1016/j.jad.2020.07.094
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China
Funding ProjectNational Natural Science Foundation of China[81571322] ; National Natural Science Foundation of China[81871060]
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000565874400014
PublisherELSEVIER
WOS KeywordOXYTOCIN RECEPTOR GENE ; JOB-SATISFACTION ; PHYSICAL HEALTH ; TEACHER BURNOUT ; SOCIAL SUPPORT ; STRESS ; RECOGNITION ; DEPRIVATION ; BRAIN ; EMPATHY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32628
Collection健康与遗传心理学研究室
Corresponding AuthorZhang, Xiang-Yang
Affiliation1.Peking Univ, Sch Psychol & Cognit Sci, Beijing 100871, Peoples R China
2.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Beijing 100871, Peoples R China
3.Renmin Univ China, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
Corresponding Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wu, Jiao,Dong, Yan,Zhao, Xue-rong,et al. Burnout in university faculty: An interaction between subjective sleep quality and the OXTR rs2268498 polymorphism[J]. JOURNAL OF AFFECTIVE DISORDERS,2020,276:927-935.
APA Wu, Jiao,Dong, Yan,Zhao, Xue-rong,He, Shu-chang,&Zhang, Xiang-Yang.(2020).Burnout in university faculty: An interaction between subjective sleep quality and the OXTR rs2268498 polymorphism.JOURNAL OF AFFECTIVE DISORDERS,276,927-935.
MLA Wu, Jiao,et al."Burnout in university faculty: An interaction between subjective sleep quality and the OXTR rs2268498 polymorphism".JOURNAL OF AFFECTIVE DISORDERS 276(2020):927-935.
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