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The effects of childhood trauma on the onset, severity and improvement of depression: The role of dysfunctional attitudes and cortisol levels
Ju, Yumeng1,2; Wang, Mi1; Lu, Xiaowen1,2; Sun, Jinrong1,2; Dong, Qiangli1,2; Zhang, Liang1,2; Liu, Bangshan1,2; Liu, Jin1,2; Yan, Danfeng1,2; Guo, Hua3; Zhao, Futao3; Liao, Mei1,2; Zhang, Xiangyang4; Zhang, Yan1,2; Li, Lingjiang1,2
First AuthorJu, Yumeng
Correspondent Emailzydd7877@csu.edu.cn (y. zhang)
2020-11-01
Source PublicationJOURNAL OF AFFECTIVE DISORDERS
ISSN0165-0327
Subtypearticle
Volume276Pages:402-410
Contribution Rank4
Abstract

Background: Childhood trauma is an important early social risk factor for the development of the major depressive disorder (MDD). Both childhood trauma and depression are associated with dysfunctional attitudes and dysregulation in stress hormones. We aimed to clarify the path from childhood trauma to depression and identify potential predictors of antidepressant treatment outcomes. Objectives: One hundred and thirty-nine MDD patients and 112 healthy controls were included at baseline. Depressive symptoms were assessed with both self-reported and expert-rated scales. Childhood trauma and dysfunctional attitudes were evaluated and blood cortisol levels were assayed. Patients received an open-label antidepressant trial with paroxetine and their depressive symptoms were monitored by the Hamilton Depression Rating Scale (HAMD) during 6 months of treatment. After 6 months, 94 patients received the same assessments as the baseline. Results: At baseline, the influence of childhood trauma on depression diagnosis was mediated by dysfunctional attitudes. In patients with MDD, the influence of childhood trauma on depression severity was mediated by both dysfunctional attitudes and cortisol levels. Baseline childhood trauma predicted the antidepressant treatment outcome during early treatment phase and baseline cortisol levels predicted the antidepressant treatment outcome at later treatment phase. After 6-month antidepressant treatment, a significant remission by time effect was found on dysfunctional attitudes and depression severity but not on cortisol levels. Conclusion: Effect of childhood trauma on depression onset was mediated by dysfunctional attitudes. The relationship between childhood trauma and depressive symptoms was mediated by dysfunctional attitudes and cortisol levels in MDD patients. Baseline childhood trauma and cortisol levels may be moderators for antidepressant treatment response at different treatment phase.

KeywordMajor depressive disorder (MDD) Childhood trauma Dysfunctional attitudes Cortisol Treatment response Mediator
DOI10.1016/j.jad.2020.07.023
Indexed BySCI
Language英语
Funding OrganizationNational Science and Technologic Program of China ; Defense Innovative Special Region Program ; National Natural Science Foundation of China
Funding ProjectNational Science and Technologic Program of China[2015BAI13B02] ; Defense Innovative Special Region Program[17-163-17-XZ-004-005-01] ; National Natural Science Foundation of China[81171286] ; National Natural Science Foundation of China[91232714] ; National Natural Science Foundation of China[81601180]
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000565879800047
PublisherELSEVIER
WOS KeywordPITUITARY-ADRENAL AXIS ; EARLY-LIFE STRESS ; FUNCTIONAL CONNECTIVITY ; EMOTION REGULATION ; MAJOR DEPRESSION ; AMYGDALA ; SYMPTOMS ; DISORDER ; BRAIN ; MALTREATMENT
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32631
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Yan
Affiliation1.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China
2.Cent South Univ, China Natl Clin Res Ctr Mental Disorders Xiangya, China Natl Technol Inst Mental Disorders, Hunan Technol Inst Psychiat,Mental Hlth Inst,Huna, Changsha 410011, Hunan, Peoples R China
3.Zhumadian Psychiat Hosp, Zhumadian 463000, Henan, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Ju, Yumeng,Wang, Mi,Lu, Xiaowen,et al. The effects of childhood trauma on the onset, severity and improvement of depression: The role of dysfunctional attitudes and cortisol levels[J]. JOURNAL OF AFFECTIVE DISORDERS,2020,276:402-410.
APA Ju, Yumeng.,Wang, Mi.,Lu, Xiaowen.,Sun, Jinrong.,Dong, Qiangli.,...&Li, Lingjiang.(2020).The effects of childhood trauma on the onset, severity and improvement of depression: The role of dysfunctional attitudes and cortisol levels.JOURNAL OF AFFECTIVE DISORDERS,276,402-410.
MLA Ju, Yumeng,et al."The effects of childhood trauma on the onset, severity and improvement of depression: The role of dysfunctional attitudes and cortisol levels".JOURNAL OF AFFECTIVE DISORDERS 276(2020):402-410.
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