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Sex differences in the association between symptoms and superoxide dismutase in patients with never-treated first-episode schizophrenia
Wang, Dong Mei1,2; Chen, Da Chun3; Wang, Li1,2; Zhang, Xiang Yang1,2
Corresponding AuthorZhang, Xiang Yang(zhangxy@psych.ac.cn)
2020-08-26
Source PublicationWORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
ISSN1562-2975
Pages10
AbstractObjectives Considering the sex differences and oxidative stress in the pathophysiological mechanism of schizophrenia (SCZ), we explored the sex differences in clinical characteristics and superoxide dismutase (SOD) activity as well as their relationship in never-treated first-episode (NTFE) patients with SCZ in the Han Chinese population, which has not been reported yet. Methods Total SOD and manganese SOD (MnSOD) activities were examined in 165 NTFE patients with SCZ (male/female = 98/67) and 133 healthy controls (male/female =70/63). Psychopathological symptoms were evaluated by a five-factor model of the Positive and Negative Syndrome Scale (PANSS). Results SCZ patients had higher plasma total SOD activity than healthy controls (p < .01). In healthy controls, the total SOD activity was significantly higher in males than that in females (p < .001), but not in patients group (p > .05). Further, Multiple regression analysis revealed that in male patients, the PANSS depressive factor was independently positively correlated with MnSOD or total SOD activity (bothp < .01), while in female patients, the MnSOD activity was positively related to the PANSS positive symptom score (p < .05). Conclusions Our findings indicate sex differences in the relationship between SOD activities and psychopathological symptoms in the early stage of SCZ.
KeywordSex differences SOD schizophrenia first-episode PANSS
DOI10.1080/15622975.2020.1805510
Indexed BySCI
Language英语
Funding OrganizationNational Key Research and Development Program of China ; CAS International Cooperation Research Program ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health
Funding ProjectNational Key Research and Development Program of China[2017YFC1310405] ; CAS International Cooperation Research Program[153111KYSB20190004] ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000566570000001
PublisherTAYLOR & FRANCIS LTD
WOS KeywordANTIOXIDANT ENZYME-ACTIVITIES ; NEGATIVE SYNDROME SCALE ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; CEREBROSPINAL-FLUID ; GENDER-DIFFERENCES ; AGE ; HALOPERIDOL ; PSYCHOSIS ; EXERCISE
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32637
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Xiang Yang
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Beijing HuiLongGuan Hosp, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Dong Mei,Chen, Da Chun,Wang, Li,et al. Sex differences in the association between symptoms and superoxide dismutase in patients with never-treated first-episode schizophrenia[J]. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY,2020:10.
APA Wang, Dong Mei,Chen, Da Chun,Wang, Li,&Zhang, Xiang Yang.(2020).Sex differences in the association between symptoms and superoxide dismutase in patients with never-treated first-episode schizophrenia.WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY,10.
MLA Wang, Dong Mei,et al."Sex differences in the association between symptoms and superoxide dismutase in patients with never-treated first-episode schizophrenia".WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY (2020):10.
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