Alternative TitleComparative and Correlative Study of Cognitive Function between Depression and Schizophrenia
陈诚1; 王高华1; 王惠玲1; 蒋田仔2; 周媛3; 吴士豪1; 黄欢1; 邹寄林1
First Author陈诚
Contribution Rank3


Other Abstract

To explore the characteristics of cognitive impairment and its relationship with factors such as age, education, clinical symptoms, and duration of illness in depression and schizophrenia patients. Methods: Thirty- six subjects were recruited to the depression group, schizophrenia group, and normal control (NC) group then were performed the Digit Symbol Test (DST), Digit Span Test (DSPT), and Verbal Fluency Test (VFT) to explore the characteristics of cognitive impairment and analyze its influencing factors. Results: Between the 3 groups, age, gender, and education showed no significant difference (P>0.05). Compared with the NC group, both depression and schizophrenia groups showed increased HAMD and HAMA scores,and this increase was more significant in the depression group (P<0.05); depression and schizophrenia groups also showed decreased DST, DSPT, and VFT scores, and this decrease was more apparent in the schizophrenia group (P<0.01). In all subjects, the DST, DSPT (backward recall), and VFT scores were positively correlated with education level, and the DSPT (forward recall) score was negatively correlated with age. In the depression group, the DST and DSPT (forward) scores were negatively correlated with HAMD scores, and the DSPT (forward) score was also negatively correlated with duration of illness (P<0.05). In the schizophrenia group, the DST score was negatively correlated with positive PANSS scores and duration of illness; the DSPT (backward) score was negatively correlated with duration of illness;the VFT score was negatively correlated with negative PANSS scores and duration of illness (P<0.05). Conclusion: Cognitive impairment is present in depression and schizophrenia patients at different levels. Compared with depressive symptoms, psychotic symptoms lead to more serious cognitive impairment. Cognitive impairment in depression patients more often affect thinking sensitivity and attention speed while in schizophrenia patients, it more often affects executive function and information extraction and processing.

Keyword抑郁症 精神分裂症 认知功能
Source Publication神经损伤与功能重建
Project Intro.

国家自然科学基金(No.91132301);; 湖北省自然科学基金(No.2014CFB732)

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Document Type期刊论文
Corresponding Author周媛
Corresponding Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
陈诚,王高华,王惠玲,等. 抑郁症与精神分裂症患者的认知功能损害特点比较[J]. 神经损伤与功能重建,2020,15(09):506-509.
APA 陈诚.,王高华.,王惠玲.,蒋田仔.,周媛.,...&邹寄林.(2020).抑郁症与精神分裂症患者的认知功能损害特点比较.神经损伤与功能重建,15(09),506-509.
MLA 陈诚,et al."抑郁症与精神分裂症患者的认知功能损害特点比较".神经损伤与功能重建 15.09(2020):506-509.
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