Discovering Traditional Chinese Medicinal Herbs for Neurodegenerative Disorders

doi:10.36468/pharmaceutical-sciences.sp1.63

	Discovering Traditional Chinese Medicinal Herbs for Neurodegenerative Disorders
	Liu, Xuewei 1; Jia, Caixia 2; Wu, Chuanhong 3; Wang, Na 1; Jia, Yongming 1; Zhu, Yongtao 2; Li, Pengyue 2; Ghulam, Murtaza 4; Zhang, Kunlin5,6
通讯作者	Ghulam, Murtaza(gmdogar356@gmail.com) ; Zhang, Kunlin(zhangkl@psych.ac.cn)
摘要	In this investigation, candidate traditional Chinese medicinal herbs for 3 neurodegenerative disorders, late-onset Alzheimer's disease, late-onset Parkinson's disease and Huntington disease were evaluated. The susceptibility genes were integrated to reconstruct traditional Chinese medicine-modern medicine network to discover the candidate herbs. For the 3 neurodegenerative disorders, the number of diseaserelated genes were increased from 2 to 16, which are directly associated with ingredients. Many traditional Chinese medicinal herbs associated with the 3 neurodegenerative disorders were identified (false discovery rate Benjamini-Hochberg<0.05). Four herbs for late-onset Alzheimer's disease are related to P-amyloid 1-42 measurement-associated genes BCAM and APOE by ingredients resveratrol and kainic acid. There are 3 herbs correlated to late-onset Parkinson's disease by both ingredient support and modern medicine symptom association evidence. Four traditional Chinese medicinal herbs are related to Huntington disease by ingredients. Available animal experiments in rats indicated that resveratrol could help to clean p-amyloid in brain to treat Alzheimer's disease, probably through targeting LRP1 protein. This study provided a novel way to utilize genetic data to explore traditional Chinese medicinal herbs and a new insight into drug discovery of neurodegenerative disorders.
关键词	Neurodegenerative disorders susceptibility gene traditional Chinese medicine herbs Alzheimer's disease resveratrol
	2020
语种	英语
DOI	10.36468/pharmaceutical-sciences.sp1.63
发表期刊	INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
ISSN	0250-474X
卷号	82 页码:70-+
收录类别	SCI
资助项目	National Natural Science Foundation of China[31470070] ; Fundamental Research Funds for the Central Universities[2018-JYB-XJQ-007] ; Fundamental Research Funds for the Central Universities[1000061020051]
出版者	INDIAN PHARMACEUTICAL ASSOC
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
WOS记录号	WOS:000566973300014
资助机构	National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/32860
专题	中国科学院心理健康重点实验室
通讯作者	Ghulam, Murtaza; Zhang, Kunlin
作者单位	1.Qiqihar Med Univ, Coll Pharm, Qiqihar 161006, Peoples R China 2.Beijing Univ Chinese Med, Beijing 100029, Peoples R China 3.Qingdao Univ, Biomed Sci Inst, Qingdao Branch, SJTU BioX Inst, Qingdao 266071, Peoples R China 4.COMSATS Univ Islamabad, Dept Pharm, Lahore Campus, Islamabad, Pakistan 5.Chinese Acad Sci, Inst Psychol, Ctr Genet & BioMed Informat Res, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xuewei,Jia, Caixia,Wu, Chuanhong,et al. Discovering Traditional Chinese Medicinal Herbs for Neurodegenerative Disorders[J]. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES,2020,82:70-+.
APA	Liu, Xuewei.,Jia, Caixia.,Wu, Chuanhong.,Wang, Na.,Jia, Yongming.,...&Zhang, Kunlin.(2020).Discovering Traditional Chinese Medicinal Herbs for Neurodegenerative Disorders.INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES,82,70-+.
MLA	Liu, Xuewei,et al."Discovering Traditional Chinese Medicinal Herbs for Neurodegenerative Disorders".INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES 82(2020):70-+.