Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia | |
Dong, Rui1; Yuan, Lian2; Yang, Yong3; Du, Xiang-Dong3; Jia, Qiufang3; Dillon, Brett A.4; Yu, Liling1; Zhang, Xiang Yang5,6 | |
第一作者 | Dong, Rui |
通讯作者邮箱 | iling07@ccmu.edu.cn (yu, liling) |
心理所单位排序 | 5 |
摘要 | Background Cognitive impairment is core feature of schizophrenia. The impact of antipsychotics on cognition remains controversial. This study aimed to examine the effects of long-term use of different types of antipsychotics on cognitive impairment in schizophrenia patients. Methods We used the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to assess the cognition of three groups of schizophrenia patients (318 on clozapine, 125 on risperidone, and 166 on typical antipsychotic drugs) and 399 healthy controls, and used the Positive and Negative Syndrome Scale to assess schizophrenia symptoms of patients. Results Patients taking typical antipsychotics scored higher on the immediate memory and delayed memory index than those taking clozapine or risperidone (allp< 0.01). Patients taking clozapine scored higher on the language subscale than those taking risperidone (p< 0.05). Multiple regression analysis showed that the drug type was identified as an independent contributor to the immediate memory, language, and delayed memory index of RBANS (allp< 0.05). Conclusions Patients taking typical antipsychotics have better memory than those taking clozapine or risperidone. Patients taking clozapine have better language function than those taking risperidone. |
关键词 | clozapine cognition risperidone schizophrenia typical antipsychotic drugs |
2020-09-17 | |
语种 | 英语 |
DOI | 10.1002/hup.2754 |
发表期刊 | HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL |
ISSN | 0885-6222 |
页码 | 8 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[81371477] ; CAS Pioneer Hundred Talents Program |
项目简介 | National Natural Science Foundation of China;CAS Pioneer Hundred Talents Program |
出版者 | WILEY |
WOS关键词 | 2ND-GENERATION ANTIPSYCHOTICS ; ATYPICAL ANTIPSYCHOTICS ; ACETYLCHOLINE-RECEPTORS ; CLOZAPINE ; RISPERIDONE ; MEMORY ; HALOPERIDOL ; IMPAIRMENT ; OLANZAPINE ; IMPACT |
WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology |
WOS类目 | Clinical Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology |
WOS记录号 | WOS:000571601700001 |
资助机构 | National Natural Science Foundation of China ; CAS Pioneer Hundred Talents Program |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/32869 |
专题 | 中国科学院心理研究所 |
通讯作者 | Yu, Liling; Zhang, Xiang Yang |
作者单位 | 1.Capital Med Univ, Coll Med Humanities, Dept Med Psychol, 10 Xitoutiao, Beijing, Peoples R China 2.Soochow Univ, Med Coll, Suzhou, Peoples R China 3.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Peoples R China 4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Dong, Rui,Yuan, Lian,Yang, Yong,et al. Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,2020:8. |
APA | Dong, Rui.,Yuan, Lian.,Yang, Yong.,Du, Xiang-Dong.,Jia, Qiufang.,...&Zhang, Xiang Yang.(2020).Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia.HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,8. |
MLA | Dong, Rui,et al."Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia".HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2020):8. |
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