PSYCH OpenIR
Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia
Dong, Rui1; Yuan, Lian2; Yang, Yong3; Du, Xiang-Dong3; Jia, Qiufang3; Dillon, Brett A.4; Yu, Liling1; Zhang, Xiang Yang5,6
First AuthorDong, Rui
Correspondent Emaililing07@ccmu.edu.cn (yu, liling)
Contribution Rank5
Abstract

Background Cognitive impairment is core feature of schizophrenia. The impact of antipsychotics on cognition remains controversial. This study aimed to examine the effects of long-term use of different types of antipsychotics on cognitive impairment in schizophrenia patients. Methods We used the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to assess the cognition of three groups of schizophrenia patients (318 on clozapine, 125 on risperidone, and 166 on typical antipsychotic drugs) and 399 healthy controls, and used the Positive and Negative Syndrome Scale to assess schizophrenia symptoms of patients. Results Patients taking typical antipsychotics scored higher on the immediate memory and delayed memory index than those taking clozapine or risperidone (allp< 0.01). Patients taking clozapine scored higher on the language subscale than those taking risperidone (p< 0.05). Multiple regression analysis showed that the drug type was identified as an independent contributor to the immediate memory, language, and delayed memory index of RBANS (allp< 0.05). Conclusions Patients taking typical antipsychotics have better memory than those taking clozapine or risperidone. Patients taking clozapine have better language function than those taking risperidone.

Keywordclozapine cognition risperidone schizophrenia typical antipsychotic drugs
2020-09-17
Language英文
DOI10.1002/hup.2754
Source PublicationHUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
ISSN0885-6222
Pages8
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81371477] ; CAS Pioneer Hundred Talents Program
Project Intro.

National Natural Science Foundation of China;CAS Pioneer Hundred Talents Program

PublisherWILEY
WOS Keyword2ND-GENERATION ANTIPSYCHOTICS ; ATYPICAL ANTIPSYCHOTICS ; ACETYLCHOLINE-RECEPTORS ; CLOZAPINE ; RISPERIDONE ; MEMORY ; HALOPERIDOL ; IMPAIRMENT ; OLANZAPINE ; IMPACT
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS SubjectClinical Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology
WOS IDWOS:000571601700001
Funding OrganizationNational Natural Science Foundation of China ; CAS Pioneer Hundred Talents Program
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32869
Collection中国科学院心理研究所
Corresponding AuthorYu, Liling; Zhang, Xiang Yang
Affiliation1.Capital Med Univ, Coll Med Humanities, Dept Med Psychol, 10 Xitoutiao, Beijing, Peoples R China
2.Soochow Univ, Med Coll, Suzhou, Peoples R China
3.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Peoples R China
4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Dong, Rui,Yuan, Lian,Yang, Yong,et al. Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,2020:8.
APA Dong, Rui.,Yuan, Lian.,Yang, Yong.,Du, Xiang-Dong.,Jia, Qiufang.,...&Zhang, Xiang Yang.(2020).Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia.HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,8.
MLA Dong, Rui,et al."Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia".HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2020):8.
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