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Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms
Wang, Yong-ming1,2,3,4; Zhang, Yi-jing1,4; Cai, Xin-lu1,2,3,4; Yang, Han-xue1,4; Shan, Hai-di5; Cheung, Eric F. C.6; Chan, Raymond C. K.1,2,3,4
Corresponding AuthorChan, Raymond C. K.(rckchan@psych.ac.cn)
AbstractAltered brain structures have been found in patients with schizo-obsessive disorder, schizophrenia and obsessive-compulsive disorder in previous studies. However, it is unclear whether similar brain changes are also found in individuals with high schizo-obsessive traits (SOT), high schizotypal traits (SCT) and obsessive-compulsive symptoms (OCS). We examined grey matter volume (GMV) and white matter integrity (WMI, including fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity) in 26 individuals with high SOT, 30 individuals with high SCT, 25 individuals with OCS and 30 individuals with low trait scores (LT) in this study. Correlation analysis between GMV, WMI, Schizotypal Personality Questionnaire (SPQ) scores and Obsessive-Compulsive Inventory-Revised (OCI-R) scores in the subclinical groups was also carried out. We found that the SOT group exhibited increased GMV at the right superior occipital gyrus and the left postcentral gyrus compared with the LT group. The SCT group exhibited increased GMV at the right precentral gyrus and the bilateral cuneus compared with the LT group, and decreased fractional anisotropy at the anterior corona radiata compared with the other three groups. The OCS group exhibited increased GMV at the left superior temporal gyrus and decreased GMV at the left pre-supplementary motor area compared with the LT group. These findings highlight specific brain changes in individuals with high SOT, high SCT and OCS, and may thus provide new insights into the neurobiological changes that occur in sub-clinical populations of these disorders.
KeywordSchizo-obsessive traits Schizotypal traits Obsessive-Compulsive Symptoms Grey matter volume White matter integrity
2020-08-01
Language英语
DOI10.1016/j.ajp.2020.102096
Source PublicationASIAN JOURNAL OF PSYCHIATRY
ISSN1876-2018
Volume52Pages:6
Indexed BySCI
Funding ProjectNational Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology
PublisherELSEVIER
WOS KeywordANTERIOR CORONA RADIATA ; BRAIN STRUCTURE ; BDNF GENE ; HIGH-RISK ; SCHIZOPHRENIA ; METAANALYSIS ; DISORDER ; ASSOCIATION ; SPECTRUM ; NEUROBIOLOGY
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000573651300004
Funding OrganizationNational Key Research and Development Programme ; Beijing Municipal Science & Technology Commission ; Beijing Training Project for the Leading Talents in S T ; CAS Key Laboratory of Mental Health, Institute of Psychology
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32878
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Sino Danish Coll, Beijing 100190, Peoples R China
3.Sino Danish Ctr Educ & Res, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Translat Neuropsychol & Appl Cognit Neurosci Lab, Sch Med, Shanghai, Peoples R China
6.Castle Peak Hosp, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yong-ming,Zhang, Yi-jing,Cai, Xin-lu,et al. Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms[J]. ASIAN JOURNAL OF PSYCHIATRY,2020,52:6.
APA Wang, Yong-ming.,Zhang, Yi-jing.,Cai, Xin-lu.,Yang, Han-xue.,Shan, Hai-di.,...&Chan, Raymond C. K..(2020).Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms.ASIAN JOURNAL OF PSYCHIATRY,52,6.
MLA Wang, Yong-ming,et al."Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms".ASIAN JOURNAL OF PSYCHIATRY 52(2020):6.
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