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| Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms | |
Wang, Yong-ming1,2,3,4; Zhang, Yi-jing1,4; Cai, Xin-lu1,2,3,4; Yang, Han-xue1,4; Shan, Hai-di5; Cheung, Eric F. C.6; Chan, Raymond C. K.1,2,3,4
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| Corresponding Author | Chan, Raymond C. K.(rckchan@psych.ac.cn) |
| Abstract | Altered brain structures have been found in patients with schizo-obsessive disorder, schizophrenia and obsessive-compulsive disorder in previous studies. However, it is unclear whether similar brain changes are also found in individuals with high schizo-obsessive traits (SOT), high schizotypal traits (SCT) and obsessive-compulsive symptoms (OCS). We examined grey matter volume (GMV) and white matter integrity (WMI, including fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity) in 26 individuals with high SOT, 30 individuals with high SCT, 25 individuals with OCS and 30 individuals with low trait scores (LT) in this study. Correlation analysis between GMV, WMI, Schizotypal Personality Questionnaire (SPQ) scores and Obsessive-Compulsive Inventory-Revised (OCI-R) scores in the subclinical groups was also carried out. We found that the SOT group exhibited increased GMV at the right superior occipital gyrus and the left postcentral gyrus compared with the LT group. The SCT group exhibited increased GMV at the right precentral gyrus and the bilateral cuneus compared with the LT group, and decreased fractional anisotropy at the anterior corona radiata compared with the other three groups. The OCS group exhibited increased GMV at the left superior temporal gyrus and decreased GMV at the left pre-supplementary motor area compared with the LT group. These findings highlight specific brain changes in individuals with high SOT, high SCT and OCS, and may thus provide new insights into the neurobiological changes that occur in sub-clinical populations of these disorders. |
| Keyword | Schizo-obsessive traits Schizotypal traits Obsessive-Compulsive Symptoms Grey matter volume White matter integrity |
| 2020-08-01 | |
| Language | 英语 |
| DOI | 10.1016/j.ajp.2020.102096 |
| Source Publication | ASIAN JOURNAL OF PSYCHIATRY
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| ISSN | 1876-2018 |
| Volume | 52Pages:6 |
| Indexed By | SCI |
| Funding Project | National Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology |
| Publisher | ELSEVIER |
| WOS Keyword | ANTERIOR CORONA RADIATA ; BRAIN STRUCTURE ; BDNF GENE ; HIGH-RISK ; SCHIZOPHRENIA ; METAANALYSIS ; DISORDER ; ASSOCIATION ; SPECTRUM ; NEUROBIOLOGY |
| WOS Research Area | Psychiatry |
| WOS Subject | Psychiatry |
| WOS ID | WOS:000573651300004 |
| Funding Organization | National Key Research and Development Programme ; Beijing Municipal Science & Technology Commission ; Beijing Training Project for the Leading Talents in S T ; CAS Key Laboratory of Mental Health, Institute of Psychology |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/32878 |
| Collection | 中国科学院心理健康重点实验室 |
| Corresponding Author | Chan, Raymond C. K. |
| Affiliation | 1.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Sino Danish Coll, Beijing 100190, Peoples R China 3.Sino Danish Ctr Educ & Res, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Translat Neuropsychol & Appl Cognit Neurosci Lab, Sch Med, Shanghai, Peoples R China 6.Castle Peak Hosp, Hong Kong, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Yong-ming,Zhang, Yi-jing,Cai, Xin-lu,et al. Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms[J]. ASIAN JOURNAL OF PSYCHIATRY,2020,52:6. |
| APA | Wang, Yong-ming.,Zhang, Yi-jing.,Cai, Xin-lu.,Yang, Han-xue.,Shan, Hai-di.,...&Chan, Raymond C. K..(2020).Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms.ASIAN JOURNAL OF PSYCHIATRY,52,6. |
| MLA | Wang, Yong-ming,et al."Altered grey matter volume and white matter integrity in individuals with high schizo-obsessive traits, high schizotypal traits and obsessive-compulsive symptoms".ASIAN JOURNAL OF PSYCHIATRY 52(2020):6. |
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| File Name/Size | DocType | Version | Access | License | ||
| Altered grey matter （798KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text | |
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