Institutional Repository of Key Laboratory of Mental Health, CAS
The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation | |
Zhou, Hao1; Wang, Jiesi2; Zhang, Yu3; Shao, Feng1; Wang, Weiwen2 | |
第一作者 | Zhou, Hao |
通讯作者邮箱 | shaof@pku.edu.cn (feng shao ) ; wangww@psych.ac.cn (weiwen wang ) |
心理所单位排序 | 2 |
摘要 | According to the microglial hypothesis of schizophrenia, the hyperactivation of microglia and the release of proinflammatory cytokines lead to neuronal loss, which is highly related to the onset of schizophrenia. Recent studies have demonstrated that fractalkine (CX3CL1) and its receptor CX3CR1 modulate the function of microglia. Thus, the present study aimed to determine whether microglial CX3CR1 plays a role in schizophrenia-related behaviors. A classical animal model of schizophrenia, social isolation (from postnatal days 21-56), was used to induce schizophrenia-related behaviors in C57BL/6J and CX3CR1(-/-)mice, and the expression of the microglial CX3CR1 protein was examined in several brain areas of the C57BL/6J mice by Western blot analysis. The results revealed that social isolation caused deficits in the prepulse inhibition (PPI) in the C57BL/6J mice but not in the CX3CR1(-/-) mice and increased locomotor activity in both the C57BL/6J mice and the CX3CR1(-/-) mice. Moreover, the CX3CR1 protein level was increased in the medial prefrontal cortex, nucleus accumbens, and hippocampus of the isolated C57BL/6J mice. These findings suggested that the function of microglia regulated by CX3CR1 might participate in schizophrenia-related behaviors. |
关键词 | CX3CR1 microglia schizophrenia social isolation prepulse inhibition |
2020-09-04 | |
DOI | 10.3389/fnint.2020.551676 |
发表期刊 | FRONTIERS IN INTEGRATIVE NEUROSCIENCE |
ISSN | 1662-5145 |
卷号 | 14页码:8 |
期刊论文类型 | 实证研究 |
收录类别 | SCI ; SSCI |
资助项目 | National Natural Science Foundation of China[31470988] ; National Natural Science Foundation of China[31771217] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences |
出版者 | FRONTIERS MEDIA SA |
WOS关键词 | BRAIN ; FRACTALKINE ; EXPRESSION ; RESILIENCE ; ACTIVATION ; CX(3)CR1 ; BLOOD ; GENE ; MICE |
WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology |
WOS类目 | Behavioral Sciences ; Neurosciences |
WOS记录号 | WOS:000573643100001 |
WOS分区 | Q3 |
资助机构 | National Natural Science Foundation of China ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/32914 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Shao, Feng; Wang, Weiwen |
作者单位 | 1.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Sch Psychol & Cognit Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 3.Binzhou Med Univ, Sch Nursing, Yantai, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Zhou, Hao,Wang, Jiesi,Zhang, Yu,et al. The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation[J]. FRONTIERS IN INTEGRATIVE NEUROSCIENCE,2020,14:8. |
APA | Zhou, Hao,Wang, Jiesi,Zhang, Yu,Shao, Feng,&Wang, Weiwen.(2020).The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation.FRONTIERS IN INTEGRATIVE NEUROSCIENCE,14,8. |
MLA | Zhou, Hao,et al."The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation".FRONTIERS IN INTEGRATIVE NEUROSCIENCE 14(2020):8. |
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