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The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation
Zhou, Hao1; Wang, Jiesi2; Zhang, Yu3; Shao, Feng1; Wang, Weiwen2
First AuthorZhou, Hao
Correspondent Emailshaof@pku.edu.cn (feng shao ) ; wangww@psych.ac.cn (weiwen wang )
Contribution Rank2
Abstract

According to the microglial hypothesis of schizophrenia, the hyperactivation of microglia and the release of proinflammatory cytokines lead to neuronal loss, which is highly related to the onset of schizophrenia. Recent studies have demonstrated that fractalkine (CX3CL1) and its receptor CX3CR1 modulate the function of microglia. Thus, the present study aimed to determine whether microglial CX3CR1 plays a role in schizophrenia-related behaviors. A classical animal model of schizophrenia, social isolation (from postnatal days 21-56), was used to induce schizophrenia-related behaviors in C57BL/6J and CX3CR1(-/-)mice, and the expression of the microglial CX3CR1 protein was examined in several brain areas of the C57BL/6J mice by Western blot analysis. The results revealed that social isolation caused deficits in the prepulse inhibition (PPI) in the C57BL/6J mice but not in the CX3CR1(-/-) mice and increased locomotor activity in both the C57BL/6J mice and the CX3CR1(-/-) mice. Moreover, the CX3CR1 protein level was increased in the medial prefrontal cortex, nucleus accumbens, and hippocampus of the isolated C57BL/6J mice. These findings suggested that the function of microglia regulated by CX3CR1 might participate in schizophrenia-related behaviors.

KeywordCX3CR1 microglia schizophrenia social isolation prepulse inhibition
2020-09-04
Language英语
DOI10.3389/fnint.2020.551676
Source PublicationFRONTIERS IN INTEGRATIVE NEUROSCIENCE
ISSN1662-5145
Volume14Pages:8
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[31470988] ; National Natural Science Foundation of China[31771217] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
PublisherFRONTIERS MEDIA SA
WOS KeywordBRAIN ; FRACTALKINE ; EXPRESSION ; RESILIENCE ; ACTIVATION ; CX(3)CR1 ; BLOOD ; GENE ; MICE
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000573643100001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32914
Collection中国科学院心理健康重点实验室
Corresponding AuthorShao, Feng; Wang, Weiwen
Affiliation1.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Sch Psychol & Cognit Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
3.Binzhou Med Univ, Sch Nursing, Yantai, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhou, Hao,Wang, Jiesi,Zhang, Yu,et al. The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation[J]. FRONTIERS IN INTEGRATIVE NEUROSCIENCE,2020,14:8.
APA Zhou, Hao,Wang, Jiesi,Zhang, Yu,Shao, Feng,&Wang, Weiwen.(2020).The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation.FRONTIERS IN INTEGRATIVE NEUROSCIENCE,14,8.
MLA Zhou, Hao,et al."The Role of Microglial CX3CR1 in Schizophrenia-Related Behaviors Induced by Social Isolation".FRONTIERS IN INTEGRATIVE NEUROSCIENCE 14(2020):8.
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