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COVID-19 and multiorgan failure: A narrative review on potential mechanisms
Mokhtari, Tahmineh1,2; Hassani, Fatemeh3; Ghaffari, Neda4; Ebrahimi, Babak4; Yarahmadi, Atousa4; Hassanzadeh, Ghomareza4,5,6
First AuthorMokhtari, Tahmineh
Correspondent Emailghomareza hassanzadeh (ghomareza hassanzadeh)
Contribution Rank1
Abstract

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in December 2019 form Wuhan, China leads to coronavirus disease 2019 (COVID-19) pandemic. While the common cold symptoms are observed in mild cases, COVID-19 is accompanied by multiorgan failure in severe patients. The involvement of different organs in severe patients results in lengthening the hospitalization duration and increasing the mortality rate. In this review, we aimed to investigate the involvement of different organs in COVID-19 patients, particularly in severe cases. Also, we tried to define the potential underlying mechanisms of SARS-CoV2 induced multiorgan failure. The multi-organ dysfunction is characterized by acute lung failure, acute liver failure, acute kidney injury, cardiovascular disease, and as well as a wide spectrum of hematological abnormalities and neurological disorders. The most important mechanisms are related to the direct and indirect pathogenic features of SARS-CoV2. Although the presence of angiotensin-converting enzyme 2, a receptor of SARS-CoV2 in the lung, heart, kidney, testis, liver, lymphocytes, and nervous system was confirmed, there are controversial findings to about the observation of SARS-CoV2 RNA in these organs. Moreover, the organ failure may be induced by the cytokine storm, a result of increased levels of inflammatory mediators, endothelial dysfunction, coagulation abnormalities, and infiltration of inflammatory cells into the organs. Therefore, further investigations are needed to detect the exact mechanisms of pathogenesis. Since the involvement of several organs in COVID-19 patients is important for clinicians, increasing their knowledge may help to improve the outcomes and decrease the rate of mortality and morbidity.

KeywordCOVID-19 SARS-CoV2 Multi-organ failure Angiotensin-converting enzyme-2 Cytokine storm Coagulation
2020-10-04
Language英语
DOI10.1007/s10735-020-09915-3
Source PublicationJOURNAL OF MOLECULAR HISTOLOGY
ISSN1567-2379
Pages16
Subtype实证研究
Indexed BySCI
PublisherSPRINGER
WOS KeywordANGIOTENSIN-CONVERTING ENZYME-2 ; RESPIRATORY SYNDROME CORONAVIRUS ; ULTRASTRUCTURAL FINDINGS ; SARS-CORONAVIRUS ; CYTOKINE STORM ; INFECTION ; ACE2 ; EXPRESSION ; PATHOGENESIS ; SARS-COV-2
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000575034300001
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32930
Collection中国科学院心理健康重点实验室
Corresponding AuthorHassanzadeh, Ghomareza
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.ACECR, Dept Embryol, Reprod Biomed Res Ctr, Royan Inst Reprod Biomed, Tehran, Iran
4.Univ Tehran Med Sci, Sch Med, Dept Anat, Tehran, Iran
5.Univ Tehran Med Sci, Sch Adv Technol Med, Dept Neurosci & Addict Studies, Tehran, Iran
6.Legal Med Org, Legal Med Res Ctr, Tehran, Iran
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Mokhtari, Tahmineh,Hassani, Fatemeh,Ghaffari, Neda,et al. COVID-19 and multiorgan failure: A narrative review on potential mechanisms[J]. JOURNAL OF MOLECULAR HISTOLOGY,2020:16.
APA Mokhtari, Tahmineh,Hassani, Fatemeh,Ghaffari, Neda,Ebrahimi, Babak,Yarahmadi, Atousa,&Hassanzadeh, Ghomareza.(2020).COVID-19 and multiorgan failure: A narrative review on potential mechanisms.JOURNAL OF MOLECULAR HISTOLOGY,16.
MLA Mokhtari, Tahmineh,et al."COVID-19 and multiorgan failure: A narrative review on potential mechanisms".JOURNAL OF MOLECULAR HISTOLOGY (2020):16.
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