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Anticardiolipin antibody and anti-beta(2) glycoprotein I antibody are potential risk markers of ischaemic stroke in Chinese adults | |
Dong, Shengyong1,2; Pei, Bin3; Xie, Wuxiang4; Wang, Jing5,6; Zeng, Qiang1,2 | |
第一作者 | Dong, Shengyong |
通讯作者邮箱 | zq301@126.com (qiang zeng) |
心理所单位排序 | 5 |
摘要 | Objectives. aCL and anti-beta(2) glycoprotein I antibody (a beta(2)GPI) are autoantibodies associated with thromboembolic diseases. Here we investigated whether they are correlated with ischaemic cardiovascular disease in a Chinese population. Methods. Serum total aCL and a beta(2)GPI isotypes (IgA, IgG or IgM, separately) were measured in 11 015 Chinese adults. Differences of antibody level between disease and non-disease groups were examined by t-test. The correlation between antibody and ischaemic cardiovascular disease was determined by logistic regression analysis. Performance of risk prediction models employed aCL or a beta(2)GPI isotypes was evaluated by C statistic, net reclassification improvement index and integrated discrimination improvement. Results. Total aCL and a beta(2)GPI isotypes maintained low levels and increased with increasing age except total aCL and a beta(2)GPI IgG in participants older than 70 years. When distinguishing ischaemic cardiovascular disease by coronary heart disease (CHD) and ischaemic stroke, the stroke group had higher levels of aCL and a beta(2)GPI isotypes than the non-stroke group, while the CHD group only had a slightly higher a beta(2)GPI IgG than non-CHD groups. aCL and a beta(2)GPI were positively correlated with stroke but not with CHD, and improved the performance of conventional risk factors for stroke risk prediction, with C statistic from 0.769 (95% CI 0.744, 0.793) to 0.777 (95% CI 0.754, 0.800) (a beta(2)GPI IgG, P = 0.0091), and 0.778 (95% CI 0.754, 0.801) (a beta(2)GPI IgA, P = 0.0793). Stroke risk could be better reclassified by aCL and a beta(2)GPI, in association with both net reclassification improvement and integrated discrimination improvement statistics (P<0.05). Conclusion. aCL and a beta(2)GPI are associated with ischaemic stroke and have added value for stroke risk prediction. |
关键词 | anticardiolipin antibody anti-beta(2)GPI antibody ischaemic stroke risk marker |
2020-08-01 | |
语种 | 英语 |
DOI | 10.1093/rheumatology/kez551 |
发表期刊 | RHEUMATOLOGY |
ISSN | 1462-0324 |
卷号 | 59期号:8页码:1834-1841 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | Ministry of Science and Technology of People's Republic of China (State Science and Technology Support Program)[2012BAI37B04] ; Logistics Support Department of People's Liberation Army of China (the Military Healthcare Programs)[15BJZ48] ; Logistics Support Department of People's Liberation Army of China (the Military Healthcare Programs)[16BJZ40] ; China Health Promotion Foundation (Health Checkup Special Grants, CHPF-2015-KLZKT) |
出版者 | OXFORD UNIV PRESS |
WOS关键词 | CORONARY-ARTERY DISEASE ; MYOCARDIAL-INFARCTION ; ANTIPHOSPHOLIPID SYNDROME ; CARDIOVASCULAR-DISEASES ; FREQUENCY |
WOS研究方向 | Rheumatology |
WOS类目 | Rheumatology |
WOS记录号 | WOS:000574336200009 |
资助机构 | Ministry of Science and Technology of People's Republic of China (State Science and Technology Support Program) ; Logistics Support Department of People's Liberation Army of China (the Military Healthcare Programs) ; China Health Promotion Foundation (Health Checkup Special Grants, CHPF-2015-KLZKT) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/32933 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Zeng, Qiang |
作者单位 | 1.Chinese Peoples Liberat Army Gen Hosp, Hlth Management Inst, Med Ctr 2, 28 Fuxing Rd, Beijing 100853, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, 28 Fuxing Rd, Beijing 100853, Peoples R China 3.EUROIMMUN Med Diagnost China Co Ltd, EUROIMMUN Acad, Beijing, Peoples R China 4.Peking Univ, Clin Res Inst, Hlth Sci Ctr, Beijing, Peoples R China 5.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Dong, Shengyong,Pei, Bin,Xie, Wuxiang,et al. Anticardiolipin antibody and anti-beta(2) glycoprotein I antibody are potential risk markers of ischaemic stroke in Chinese adults[J]. RHEUMATOLOGY,2020,59(8):1834-1841. |
APA | Dong, Shengyong,Pei, Bin,Xie, Wuxiang,Wang, Jing,&Zeng, Qiang.(2020).Anticardiolipin antibody and anti-beta(2) glycoprotein I antibody are potential risk markers of ischaemic stroke in Chinese adults.RHEUMATOLOGY,59(8),1834-1841. |
MLA | Dong, Shengyong,et al."Anticardiolipin antibody and anti-beta(2) glycoprotein I antibody are potential risk markers of ischaemic stroke in Chinese adults".RHEUMATOLOGY 59.8(2020):1834-1841. |
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