Institutional Repository of Key Laboratory of Mental Health, CAS
Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia | |
Huang, Yuanyuan1; Wu, Kai2,3,4,5,6,7; Li, Hehua1; Zhou, Jing2,3; Xiong, Dongsheng2,3; Huang, Xia2,3; Li, Jiahui2,3; Liu, Ya2,3; Pan, Zhilin2,3; Mitchell, David T.8; Wu, Fengchun1,3; Zhang, Xiang Yang1,9 | |
第一作者 | Huang, Yuanyuan |
通讯作者邮箱 | 13580380071@163.com (wu, fengchun) ; zhangxy@psych.ac.cn (zhangxy@psych.ac.cn) |
摘要 | Obesity is common comorbidity in patients with schizophrenia. Previous studies have reported that homocysteine (Hcy) is increased in schizophrenia. However, no study has reported the association between BMI and Hcy levels in schizophrenia. This cross-sectional naturalistic study aimed to evaluate the relationship between BMI, Hcy and clinical symptoms in Chinese Han patients with chronic schizophrenia. Clinical and anthropometric data as well as plasma Hcy level and glycolipid parameters were collected. Psychopathology was measured with the Positive and Negative Syndrome Scale (PANSS). Our results showed that compared with the low BMI group, the high BMI group had a higher PANSS general psychopathology subscore, higher levels of blood glucose, total cholesterol and high-density lipoprotein (HDL) cholesterol (all p < 0.05). Hcy levels were negatively associated with BMI in patients (p < 0.001). Hcy level, the PANSS general psychopathology subscale, total cholesterol and education (all p < 0.05) were the influencing factors of high BMI. Our study suggest that Hcy level may be associated with BMI in patients with schizophrenia. Moreover, patients with high BMI show more severe clinical symptoms and higher glucose and lipid levels. |
2020-09-30 | |
DOI | 10.1038/s41598-020-72934-3 |
发表期刊 | SCIENTIFIC REPORTS |
ISSN | 2045-2322 |
卷号 | 10期号:1页码:8 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China (NSFC)[31771074] ; National Natural Science Foundation of China (NSFC)[81802230] ; Science and Technology Plan Project of Guangdong Province[2018B030335001] ; Science and Technology Plan Project of Guangdong Province[2019B030316001] ; Science and Technology Program of Guangzhou[2017A040405059] ; Science and Technology Program of Guangzhou[201804010259] ; Science and Technology Program of Guangzhou[201704020168] ; Science and Technology Program of Guangzhou[201704020113] ; Science and Technology Program of Guangzhou[201807010064] ; Science and Technology Program of Guangzhou[201803010100] ; Science and Technology Program of Guangzhou[201903010032] ; Science and Technology Project of Liwan District[201804011] |
出版者 | NATURE RESEARCH |
WOS关键词 | DRUG-NAIVE ; METHYLENETETRAHYDROFOLATE REDUCTASE ; BIPOLAR DISORDER ; WEIGHT-GAIN ; OBESITY ; RISK ; PREVALENCE ; SYMPTOMS ; CHILDREN ; DIET |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000577212800031 |
资助机构 | National Natural Science Foundation of China (NSFC) ; Science and Technology Plan Project of Guangdong Province ; Science and Technology Program of Guangzhou ; Science and Technology Project of Liwan District |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/32977 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wu, Fengchun; Zhang, Xiang Yang |
作者单位 | 1.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Dept Psychiat, 36 Mingxin Rd, Guangzhou, Peoples R China 2.South China Univ Technol SCUT, Sch Mat Sci & Engn, Dept Biomed Engn, Guangzhou, Peoples R China 3.Guangdong Engn Technol Res Ctr Translat Med Menta, Guangzhou, Peoples R China 4.Guangdong Engn Technol Res Ctr Diag & Rehabil Dem, Guangzhou, Peoples R China 5.South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou, Peoples R China 6.South China Univ Technol, Key Lab Biomed Engn Guangdong Prov, Guangzhou, Peoples R China 7.Tohoku Univ, Inst Dev Aging & Canc, Dept Nucl Med & Radiol, Sendai, Miyagi, Japan 8.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX USA 9.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Huang, Yuanyuan,Wu, Kai,Li, Hehua,et al. Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia[J]. SCIENTIFIC REPORTS,2020,10(1):8. |
APA | Huang, Yuanyuan.,Wu, Kai.,Li, Hehua.,Zhou, Jing.,Xiong, Dongsheng.,...&Zhang, Xiang Yang.(2020).Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia.SCIENTIFIC REPORTS,10(1),8. |
MLA | Huang, Yuanyuan,et al."Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia".SCIENTIFIC REPORTS 10.1(2020):8. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Homocysteine level, (1000KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论