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Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia
Huang, Yuanyuan1; Wu, Kai2,3,4,5,6,7; Li, Hehua1; Zhou, Jing2,3; Xiong, Dongsheng2,3; Huang, Xia2,3; Li, Jiahui2,3; Liu, Ya2,3; Pan, Zhilin2,3; Mitchell, David T.8; Wu, Fengchun1,3; Zhang, Xiang Yang1,9
First AuthorHuang, Yuanyuan
Correspondent Email13580380071@163.com (wu, fengchun) ; zhangxy@psych.ac.cn (zhangxy@psych.ac.cn)
Abstract

Obesity is common comorbidity in patients with schizophrenia. Previous studies have reported that homocysteine (Hcy) is increased in schizophrenia. However, no study has reported the association between BMI and Hcy levels in schizophrenia. This cross-sectional naturalistic study aimed to evaluate the relationship between BMI, Hcy and clinical symptoms in Chinese Han patients with chronic schizophrenia. Clinical and anthropometric data as well as plasma Hcy level and glycolipid parameters were collected. Psychopathology was measured with the Positive and Negative Syndrome Scale (PANSS). Our results showed that compared with the low BMI group, the high BMI group had a higher PANSS general psychopathology subscore, higher levels of blood glucose, total cholesterol and high-density lipoprotein (HDL) cholesterol (all p < 0.05). Hcy levels were negatively associated with BMI in patients (p < 0.001). Hcy level, the PANSS general psychopathology subscale, total cholesterol and education (all p < 0.05) were the influencing factors of high BMI. Our study suggest that Hcy level may be associated with BMI in patients with schizophrenia. Moreover, patients with high BMI show more severe clinical symptoms and higher glucose and lipid levels.

2020-09-30
DOI10.1038/s41598-020-72934-3
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume10Issue:1Pages:8
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China (NSFC)[31771074] ; National Natural Science Foundation of China (NSFC)[81802230] ; Science and Technology Plan Project of Guangdong Province[2018B030335001] ; Science and Technology Plan Project of Guangdong Province[2019B030316001] ; Science and Technology Program of Guangzhou[2017A040405059] ; Science and Technology Program of Guangzhou[201804010259] ; Science and Technology Program of Guangzhou[201704020168] ; Science and Technology Program of Guangzhou[201704020113] ; Science and Technology Program of Guangzhou[201807010064] ; Science and Technology Program of Guangzhou[201803010100] ; Science and Technology Program of Guangzhou[201903010032] ; Science and Technology Project of Liwan District[201804011]
PublisherNATURE RESEARCH
WOS KeywordDRUG-NAIVE ; METHYLENETETRAHYDROFOLATE REDUCTASE ; BIPOLAR DISORDER ; WEIGHT-GAIN ; OBESITY ; RISK ; PREVALENCE ; SYMPTOMS ; CHILDREN ; DIET
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000577212800031
Funding OrganizationNational Natural Science Foundation of China (NSFC) ; Science and Technology Plan Project of Guangdong Province ; Science and Technology Program of Guangzhou ; Science and Technology Project of Liwan District
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/32977
Collection中国科学院心理健康重点实验室
Corresponding AuthorWu, Fengchun; Zhang, Xiang Yang
Affiliation1.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Dept Psychiat, 36 Mingxin Rd, Guangzhou, Peoples R China
2.South China Univ Technol SCUT, Sch Mat Sci & Engn, Dept Biomed Engn, Guangzhou, Peoples R China
3.Guangdong Engn Technol Res Ctr Translat Med Menta, Guangzhou, Peoples R China
4.Guangdong Engn Technol Res Ctr Diag & Rehabil Dem, Guangzhou, Peoples R China
5.South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou, Peoples R China
6.South China Univ Technol, Key Lab Biomed Engn Guangdong Prov, Guangzhou, Peoples R China
7.Tohoku Univ, Inst Dev Aging & Canc, Dept Nucl Med & Radiol, Sendai, Miyagi, Japan
8.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX USA
9.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Huang, Yuanyuan,Wu, Kai,Li, Hehua,et al. Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia[J]. SCIENTIFIC REPORTS,2020,10(1):8.
APA Huang, Yuanyuan.,Wu, Kai.,Li, Hehua.,Zhou, Jing.,Xiong, Dongsheng.,...&Zhang, Xiang Yang.(2020).Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia.SCIENTIFIC REPORTS,10(1),8.
MLA Huang, Yuanyuan,et al."Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia".SCIENTIFIC REPORTS 10.1(2020):8.
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