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Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia | |
Huang, Yuanyuan1; Wu, Kai2,3,4,5,6,7; Li, Hehua1; Zhou, Jing2,3; Xiong, Dongsheng2,3; Huang, Xia2,3; Li, Jiahui2,3; Liu, Ya2,3; Pan, Zhilin2,3; Mitchell, David T.8; Wu, Fengchun1,3; Zhang, Xiang Yang1,9![]() | |
First Author | Huang, Yuanyuan |
Correspondent Email | 13580380071@163.com (wu, fengchun) ; zhangxy@psych.ac.cn (zhangxy@psych.ac.cn) |
Abstract | Obesity is common comorbidity in patients with schizophrenia. Previous studies have reported that homocysteine (Hcy) is increased in schizophrenia. However, no study has reported the association between BMI and Hcy levels in schizophrenia. This cross-sectional naturalistic study aimed to evaluate the relationship between BMI, Hcy and clinical symptoms in Chinese Han patients with chronic schizophrenia. Clinical and anthropometric data as well as plasma Hcy level and glycolipid parameters were collected. Psychopathology was measured with the Positive and Negative Syndrome Scale (PANSS). Our results showed that compared with the low BMI group, the high BMI group had a higher PANSS general psychopathology subscore, higher levels of blood glucose, total cholesterol and high-density lipoprotein (HDL) cholesterol (all p < 0.05). Hcy levels were negatively associated with BMI in patients (p < 0.001). Hcy level, the PANSS general psychopathology subscale, total cholesterol and education (all p < 0.05) were the influencing factors of high BMI. Our study suggest that Hcy level may be associated with BMI in patients with schizophrenia. Moreover, patients with high BMI show more severe clinical symptoms and higher glucose and lipid levels. |
2020-09-30 | |
DOI | 10.1038/s41598-020-72934-3 |
Source Publication | SCIENTIFIC REPORTS
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ISSN | 2045-2322 |
Volume | 10Issue:1Pages:8 |
Subtype | 实证研究 |
Indexed By | SCI |
Funding Project | National Natural Science Foundation of China (NSFC)[31771074] ; National Natural Science Foundation of China (NSFC)[81802230] ; Science and Technology Plan Project of Guangdong Province[2018B030335001] ; Science and Technology Plan Project of Guangdong Province[2019B030316001] ; Science and Technology Program of Guangzhou[2017A040405059] ; Science and Technology Program of Guangzhou[201804010259] ; Science and Technology Program of Guangzhou[201704020168] ; Science and Technology Program of Guangzhou[201704020113] ; Science and Technology Program of Guangzhou[201807010064] ; Science and Technology Program of Guangzhou[201803010100] ; Science and Technology Program of Guangzhou[201903010032] ; Science and Technology Project of Liwan District[201804011] |
Publisher | NATURE RESEARCH |
WOS Keyword | DRUG-NAIVE ; METHYLENETETRAHYDROFOLATE REDUCTASE ; BIPOLAR DISORDER ; WEIGHT-GAIN ; OBESITY ; RISK ; PREVALENCE ; SYMPTOMS ; CHILDREN ; DIET |
WOS Research Area | Science & Technology - Other Topics |
WOS Subject | Multidisciplinary Sciences |
WOS ID | WOS:000577212800031 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.psych.ac.cn/handle/311026/32977 |
Collection | 中国科学院心理健康重点实验室 |
Corresponding Author | Wu, Fengchun; Zhang, Xiang Yang |
Affiliation | 1.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Dept Psychiat, 36 Mingxin Rd, Guangzhou, Peoples R China 2.South China Univ Technol SCUT, Sch Mat Sci & Engn, Dept Biomed Engn, Guangzhou, Peoples R China 3.Guangdong Engn Technol Res Ctr Translat Med Menta, Guangzhou, Peoples R China 4.Guangdong Engn Technol Res Ctr Diag & Rehabil Dem, Guangzhou, Peoples R China 5.South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou, Peoples R China 6.South China Univ Technol, Key Lab Biomed Engn Guangdong Prov, Guangzhou, Peoples R China 7.Tohoku Univ, Inst Dev Aging & Canc, Dept Nucl Med & Radiol, Sendai, Miyagi, Japan 8.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX USA 9.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China |
Corresponding Author Affilication | Key Laboratory of Mental Health, CAS |
Recommended Citation GB/T 7714 | Huang, Yuanyuan,Wu, Kai,Li, Hehua,et al. Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia[J]. SCIENTIFIC REPORTS,2020,10(1):8. |
APA | Huang, Yuanyuan.,Wu, Kai.,Li, Hehua.,Zhou, Jing.,Xiong, Dongsheng.,...&Zhang, Xiang Yang.(2020).Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia.SCIENTIFIC REPORTS,10(1),8. |
MLA | Huang, Yuanyuan,et al."Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia".SCIENTIFIC REPORTS 10.1(2020):8. |
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Homocysteine level, (1000KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text |
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