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Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia
He, Yuwen1,2; Wu, Shihao3; Chen, Cheng3; Fan, Lingzhong4; Li, Kaixin5; Wang, Gaohua3; Wang, Huiling3; Zhou, Yuan1,2,6
First AuthorHe, Yuwen
Correspondent Emailzhouyuan@psych.ac.cn (y. zhou)
Contribution Rank1
Abstract

Schizophrenia has prominent functional dysconnectivity, especially in the prefrontal cortex (PFC). However, it is unclear whether in the same group of patients with schizophrenia, PFC functional dysconnectivity appears in an organized manner or is stochastically located in different subregions. By investigating the restingstate functional connectivity (rsFC) of each PFC subregion from the Brainnetome atlas in 40 schizophrenia patients and 40 healthy subjects, we found 24 altered connections in schizophrenia, and the connections were divided into four categories by a clustering analysis: increased connections within the PFC, increased connections between the inferior PFC and the thalamus/striatum, reduced connections between the PFC and the motor control areas, and reduced connections between the orbital PFC and the emotional perception regions. In addition, the four categories of rsFC showed distinct cognitive engagement patterns. Our findings suggest that PFC subregions have specific functional dysconnectivity patterns in schizophrenia and may reflect heterogeneous symptoms and cognitive deficits in schizophrenia. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

Keywordprefrontal cortex schizophrenia Brief Assessment of Cognition in Schizophrenia dysconnectivity hypothesis resting-state functional connectivity
2020-10-15
DOI10.1016/j.neuroscience.2020.08.021
Source PublicationNEUROSCIENCE
ISSN0306-4522
Volume446Pages:14-27
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81771473] ; National Natural Science Foundation of China[81371476] ; National Natural Science Foundation of China[91432302]
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS KeywordNEUROLOGICAL SOFT SIGNS ; BRAIN NETWORKS ; PARANOID SCHIZOPHRENIA ; WORKING-MEMORY ; HEAD MOTION ; CONNECTIVITY ; FMRI ; DYSFUNCTION ; ASSOCIATION ; COGNITION
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000577243000002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/33006
Collection中国科学院行为科学重点实验室
Corresponding AuthorZhou, Yuan
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, 16 Lincui Rd, Beijing 100101, Peoples R China
3.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
5.Harbin Univ Sci & Technol, Harbin 150080, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
First Author AffilicationKey Laboratory of Behavioral Science, CAS
Corresponding Author AffilicationKey Laboratory of Behavioral Science, CAS
Recommended Citation
GB/T 7714
He, Yuwen,Wu, Shihao,Chen, Cheng,et al. Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia[J]. NEUROSCIENCE,2020,446:14-27.
APA He, Yuwen.,Wu, Shihao.,Chen, Cheng.,Fan, Lingzhong.,Li, Kaixin.,...&Zhou, Yuan.(2020).Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia.NEUROSCIENCE,446,14-27.
MLA He, Yuwen,et al."Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia".NEUROSCIENCE 446(2020):14-27.
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