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Elevated activity of plasma superoxide dismutase in never-treated first-episode schizophrenia patients: Associated with depressive symptoms | |
Lang, XiaoE1; Wang, Dong Mei2,3; Du, Xiang Dong4; Jia, Qiu Fang4; Chen, Da Chun5; Xiu, Meihong5; Wang, Li2,3; Zhang, XiangYang2,3 | |
第一作者 | Lang, XiaoE |
通讯作者邮箱 | zhangxy@psych.ac.cn (x. zhang) |
心理所单位排序 | 2 |
摘要 | Oxidative stress in excess may be engaged in the pathophysiological development of schizophrenia (SCZ). Previous research showed altered activity of superoxide dismutase (SOD) in patients suffering from SCZ, with inconsistent results. However, few studies have analyzed the relationship between SOD activity and psychopathological symptoms in never-treated first-episode (NTFE) patients with SCZ. The activities of manganese SOD (MnSOD) and total SOD were measured in a large sample of 166 NTFE patients with SCZ, and 133 healthy controls. The patients' symptoms were evaluated by the Positive and Negative Syndrome Scale (PANSS), as well as the depressive and cognitive factors originated from the PANSS five-factor model. NTFE patients had significantly higher activities of MnSOD and total SOD than healthy controls (both p < 0.01). Correlation analysis displayed a notably positive correlation between both MnSOD or total SOD activities and the PANSS depressive factor, as well as between MnSOD activity and the PANSS general psychopathology subscale score (all p < 0.05). Stepwise multiple regression analysis revealed that both MnSOD and total SOD were independent factors affecting PANSS depressive factor and PANSS general psychopathology subscale score. Our findings suggest that increased SOD activity may be associated with comorbid depressive symptoms in NTFE patients with SCZ. (c) 2020 Published by Elsevier B.V. |
关键词 | Superoxide dismutase Schizophrenia Never-treated first episode |
2020-08-01 | |
DOI | 10.1016/j.schres.2020.05.032 |
发表期刊 | SCHIZOPHRENIA RESEARCH |
ISSN | 0920-9964 |
卷号 | 222页码:291-296 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | Key Research Project in Shanxi Province[201803D31098] ; Wu Jieping Medical Foundation[320.6750.18336] ; National Key Research and Development Program of China[2017YFC1310405] ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health |
出版者 | ELSEVIER |
WOS关键词 | NEGATIVE SYNDROME SCALE ; OXIDATIVE STRESS ; ANTIOXIDANT DEFENSE ; DRUG-NAIVE ; ALA-9VAL POLYMORPHISM ; 5-FACTOR MODEL ; DAMAGE ; HALOPERIDOL ; CATALASE ; ENZYMES |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000579854800037 |
资助机构 | Key Research Project in Shanxi Province ; Wu Jieping Medical Foundation ; National Key Research and Development Program of China ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/33047 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Lang, XiaoE; Wang, Dong Mei; Zhang, XiangYang |
作者单位 | 1.Shanxi Med Univ, Clin Med Coll 1, Hosp 1, Dept Psychiat, Taiyuan, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Soodhow Univ, Suzhou Psychiat Hosp, Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China 5.Beijing Huilongguan Hosp, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Lang, XiaoE,Wang, Dong Mei,Du, Xiang Dong,et al. Elevated activity of plasma superoxide dismutase in never-treated first-episode schizophrenia patients: Associated with depressive symptoms[J]. SCHIZOPHRENIA RESEARCH,2020,222:291-296. |
APA | Lang, XiaoE.,Wang, Dong Mei.,Du, Xiang Dong.,Jia, Qiu Fang.,Chen, Da Chun.,...&Zhang, XiangYang.(2020).Elevated activity of plasma superoxide dismutase in never-treated first-episode schizophrenia patients: Associated with depressive symptoms.SCHIZOPHRENIA RESEARCH,222,291-296. |
MLA | Lang, XiaoE,et al."Elevated activity of plasma superoxide dismutase in never-treated first-episode schizophrenia patients: Associated with depressive symptoms".SCHIZOPHRENIA RESEARCH 222(2020):291-296. |
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