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Elevated activity of plasma superoxide dismutase in never-treated first-episode schizophrenia patients: Associated with depressive symptoms
Lang, XiaoE1; Wang, Dong Mei2,3; Du, Xiang Dong4; Jia, Qiu Fang4; Chen, Da Chun5; Xiu, Meihong5; Wang, Li2,3; Zhang, XiangYang2,3
First AuthorLang, XiaoE
Correspondent Emailzhangxy@psych.ac.cn (x. zhang)
Contribution Rank2
Abstract

Oxidative stress in excess may be engaged in the pathophysiological development of schizophrenia (SCZ). Previous research showed altered activity of superoxide dismutase (SOD) in patients suffering from SCZ, with inconsistent results. However, few studies have analyzed the relationship between SOD activity and psychopathological symptoms in never-treated first-episode (NTFE) patients with SCZ. The activities of manganese SOD (MnSOD) and total SOD were measured in a large sample of 166 NTFE patients with SCZ, and 133 healthy controls. The patients' symptoms were evaluated by the Positive and Negative Syndrome Scale (PANSS), as well as the depressive and cognitive factors originated from the PANSS five-factor model. NTFE patients had significantly higher activities of MnSOD and total SOD than healthy controls (both p < 0.01). Correlation analysis displayed a notably positive correlation between both MnSOD or total SOD activities and the PANSS depressive factor, as well as between MnSOD activity and the PANSS general psychopathology subscale score (all p < 0.05). Stepwise multiple regression analysis revealed that both MnSOD and total SOD were independent factors affecting PANSS depressive factor and PANSS general psychopathology subscale score. Our findings suggest that increased SOD activity may be associated with comorbid depressive symptoms in NTFE patients with SCZ. (c) 2020 Published by Elsevier B.V.

KeywordSuperoxide dismutase Schizophrenia Never-treated first episode
2020-08-01
DOI10.1016/j.schres.2020.05.032
Source PublicationSCHIZOPHRENIA RESEARCH
ISSN0920-9964
Volume222Pages:291-296
Subtype实证研究
Indexed BySCI
Funding ProjectKey Research Project in Shanxi Province[201803D31098] ; Wu Jieping Medical Foundation[320.6750.18336] ; National Key Research and Development Program of China[2017YFC1310405] ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health
PublisherELSEVIER
WOS KeywordNEGATIVE SYNDROME SCALE ; OXIDATIVE STRESS ; ANTIOXIDANT DEFENSE ; DRUG-NAIVE ; ALA-9VAL POLYMORPHISM ; 5-FACTOR MODEL ; DAMAGE ; HALOPERIDOL ; CATALASE ; ENZYMES
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000579854800037
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/33047
Collection中国科学院心理健康重点实验室
Corresponding AuthorLang, XiaoE; Wang, Dong Mei; Zhang, XiangYang
Affiliation1.Shanxi Med Univ, Clin Med Coll 1, Hosp 1, Dept Psychiat, Taiyuan, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Soodhow Univ, Suzhou Psychiat Hosp, Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China
5.Beijing Huilongguan Hosp, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Lang, XiaoE,Wang, Dong Mei,Du, Xiang Dong,et al. Elevated activity of plasma superoxide dismutase in never-treated first-episode schizophrenia patients: Associated with depressive symptoms[J]. SCHIZOPHRENIA RESEARCH,2020,222:291-296.
APA Lang, XiaoE.,Wang, Dong Mei.,Du, Xiang Dong.,Jia, Qiu Fang.,Chen, Da Chun.,...&Zhang, XiangYang.(2020).Elevated activity of plasma superoxide dismutase in never-treated first-episode schizophrenia patients: Associated with depressive symptoms.SCHIZOPHRENIA RESEARCH,222,291-296.
MLA Lang, XiaoE,et al."Elevated activity of plasma superoxide dismutase in never-treated first-episode schizophrenia patients: Associated with depressive symptoms".SCHIZOPHRENIA RESEARCH 222(2020):291-296.
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