Sex-differential associations between cognitive impairments and white matter abnormalities in first episode and drug-naive schizophrenia

doi:10.1111/eip.13059

	Sex-differential associations between cognitive impairments and white matter abnormalities in first episode and drug-naive schizophrenia
	Yang, Mi 1,2,3; Gao, Shan 1; Xiong, Weisen 1,2,3; Zhang, Xiang Yang4,5
通讯作者	Zhang, Xiang Yang(zhangxy@psych.ac.cn)
摘要	Aim Previous evidence has suggested that schizophrenia patients may display sex differences in cognitive impairments and cognitive impairments are related to disrupted white matter (WM) microstructure. The current research aims to address the intriguing possibility for the sex-specific association between cognitive deficits and WM abnormalities in first-episode and drug-naive schizophrenia. Methods Cognitive performance on the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) was measured in 39 FEND patients (females:males = 23:16) and 30 healthy controls (females:males = 17:13), together with whole-brain WM fractional anisotropy (FA) values determined using voxel-based diffusion tensor imaging. Correlations between cognitive performance and FA values were assessed. Results Patients performed significantly worse than healthy controls in the total score and most of the subscores of MCCB. Female patients displayed better cognitive performance than male patients on the Trail Making A Test, the Hopkins Verbal Learning Test and the Spatial Span Test in the Wechsler Memory Scale. More importantly, sex-differential association between cognitive performance and FA values was found in patients, but not in healthy controls. In particular, FA values in the cerebellum were negatively correlated with the continuous performance and digital sequence scores in male patients but positively correlated with the performance on the Spatial Span Test in the Wechsler Memory Scale in female patients. Conclusions These findings suggest sex-specific neurobiological substrates involved in cognitive deficits in early-onset schizophrenia and have important implications for differentially targeted interventions between males and females.
关键词	cognitive impairment first episode schizophrenia sex difference white matter
	2020-10-15
语种	英语
DOI	10.1111/eip.13059
发表期刊	EARLY INTERVENTION IN PSYCHIATRY
ISSN	1751-7885
页码	9
收录类别	SCI
资助项目	National Natural Science Foundation of China[61806042] ; National Natural Science Foundation of China[31600880]
出版者	WILEY
WOS关键词	DIFFUSION TENSOR ; NEUROPSYCHOLOGICAL PERFORMANCE ; ONSET SCHIZOPHRENIA ; GENDER-DIFFERENCES ; CLINICAL-TRIALS ; INTEGRITY ; MICROSTRUCTURE ; 1ST-EPISODE ; BRAIN
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000577744500001
资助机构	National Natural Science Foundation of China
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/33050
专题	中国科学院心理健康重点实验室
通讯作者	Zhang, Xiang Yang
作者单位	1.Univ Elect Sci & Technol China, Clin Hosp, Chengdu Brain Sci Inst, MOE Key Lab NeuroInformat, Chengdu, Peoples R China 2.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu, Peoples R China 3.Fourth Peoples Hosp Chengdu, Chengdu, Peoples R China 4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yang, Mi,Gao, Shan,Xiong, Weisen,et al. Sex-differential associations between cognitive impairments and white matter abnormalities in first episode and drug-naive schizophrenia[J]. EARLY INTERVENTION IN PSYCHIATRY,2020:9.
APA	Yang, Mi,Gao, Shan,Xiong, Weisen,&Zhang, Xiang Yang.(2020).Sex-differential associations between cognitive impairments and white matter abnormalities in first episode and drug-naive schizophrenia.EARLY INTERVENTION IN PSYCHIATRY,9.
MLA	Yang, Mi,et al."Sex-differential associations between cognitive impairments and white matter abnormalities in first episode and drug-naive schizophrenia".EARLY INTERVENTION IN PSYCHIATRY (2020):9.

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