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Sex-differential associations between cognitive impairments and white matter abnormalities in first episode and drug-naive schizophrenia
Yang, Mi1,2,3; Gao, Shan1; Xiong, Weisen1,2,3; Zhang, Xiang Yang4,5
Corresponding AuthorZhang, Xiang Yang(zhangxy@psych.ac.cn)
AbstractAim Previous evidence has suggested that schizophrenia patients may display sex differences in cognitive impairments and cognitive impairments are related to disrupted white matter (WM) microstructure. The current research aims to address the intriguing possibility for the sex-specific association between cognitive deficits and WM abnormalities in first-episode and drug-naive schizophrenia. Methods Cognitive performance on the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) was measured in 39 FEND patients (females:males = 23:16) and 30 healthy controls (females:males = 17:13), together with whole-brain WM fractional anisotropy (FA) values determined using voxel-based diffusion tensor imaging. Correlations between cognitive performance and FA values were assessed. Results Patients performed significantly worse than healthy controls in the total score and most of the subscores of MCCB. Female patients displayed better cognitive performance than male patients on the Trail Making A Test, the Hopkins Verbal Learning Test and the Spatial Span Test in the Wechsler Memory Scale. More importantly, sex-differential association between cognitive performance and FA values was found in patients, but not in healthy controls. In particular, FA values in the cerebellum were negatively correlated with the continuous performance and digital sequence scores in male patients but positively correlated with the performance on the Spatial Span Test in the Wechsler Memory Scale in female patients. Conclusions These findings suggest sex-specific neurobiological substrates involved in cognitive deficits in early-onset schizophrenia and have important implications for differentially targeted interventions between males and females.
Keywordcognitive impairment first episode schizophrenia sex difference white matter
2020-10-15
Language英语
DOI10.1111/eip.13059
Source PublicationEARLY INTERVENTION IN PSYCHIATRY
ISSN1751-7885
Pages9
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[61806042] ; National Natural Science Foundation of China[31600880]
PublisherWILEY
WOS KeywordDIFFUSION TENSOR ; NEUROPSYCHOLOGICAL PERFORMANCE ; ONSET SCHIZOPHRENIA ; GENDER-DIFFERENCES ; CLINICAL-TRIALS ; INTEGRITY ; MICROSTRUCTURE ; 1ST-EPISODE ; BRAIN
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000577744500001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/33050
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Xiang Yang
Affiliation1.Univ Elect Sci & Technol China, Clin Hosp, Chengdu Brain Sci Inst, MOE Key Lab NeuroInformat, Chengdu, Peoples R China
2.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu, Peoples R China
3.Fourth Peoples Hosp Chengdu, Chengdu, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Yang, Mi,Gao, Shan,Xiong, Weisen,et al. Sex-differential associations between cognitive impairments and white matter abnormalities in first episode and drug-naive schizophrenia[J]. EARLY INTERVENTION IN PSYCHIATRY,2020:9.
APA Yang, Mi,Gao, Shan,Xiong, Weisen,&Zhang, Xiang Yang.(2020).Sex-differential associations between cognitive impairments and white matter abnormalities in first episode and drug-naive schizophrenia.EARLY INTERVENTION IN PSYCHIATRY,9.
MLA Yang, Mi,et al."Sex-differential associations between cognitive impairments and white matter abnormalities in first episode and drug-naive schizophrenia".EARLY INTERVENTION IN PSYCHIATRY (2020):9.
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