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The Role of the Subthalamic Nucleus in Sequential Working Memory in De Novo Parkinson's Disease
Ye, Zheng1; Zhang, Guanyu2,3; Zhang, Yingshuang4; Li, Shuaiqi5; Liu, Na4; Zhou, Xiaolin5,6; Xiao, Weizhong4; Munte, Thomas F.7
First AuthorYe, Zheng
Correspondent Emailyez@ion.ac.cn (zheng ye) ; thomas.muente@neuro.uni-luebeck.de (thomas f. münte) ; zhangys0317@126.com (yingshuang zhang)
Contribution Rank2
Abstract

Background Deficits in maintaining and manipulating sequential information online can occur even in patients with mild Parkinson's disease. The subthalamic nucleus may play a modulatory role in the neural system for sequential working memory, which also includes the lateral prefrontal cortex. Objectives The objective of this study was to investigate neural markers of sequential working memory deficits in patients with de novo Parkinson's disease. Methods A total of 50 patients with de novo Parkinson's disease and 50 healthy controls completed a digit ordering task during functional magnetic resonance imaging scanning. The task separated the maintenance ("pure recall") and manipulation of sequences ("reorder & recall" vs. "pure recall"). Results In healthy controls, individual participants' task accuracy was predicted by the regional activation and functional connectivity of the subthalamic nucleus. Healthy participants who showed lower subthalamic nucleus activation and stronger subthalamic nucleus connectivity with the putamen performed more accurately in maintaining sequences ("pure recall"). Healthy participants who showed greater ordering-related subthalamic nucleus activation change exhibited smaller accuracy costs in manipulating sequences ("reorder & recall" vs. "pure recall"). Patients performed less accurately than healthy controls, especially in "reorder & recall" trials, accompanied by an overactivation in the subthalamic nucleus and a loss of synchrony between the subthalamic nucleus and putamen. Individual patients' task accuracy was predicted only by the subthalamic nucleus connectivity. The contribution of the subthalamic nucleus activation or activation change was absent. We observed no change in the lateral prefrontal cortex. Conclusions The overactivation and weakened functional connectivity of the subthalamic nucleus are the neural markers of sequential working memory deficits in de novo Parkinson's disease. (c) 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC. on behalf of International Parkinson and Movement Disorder Society

KeywordfMRI Parkinson&apos s disease sequential working memory subthalamic nucleus
2020-10-24
Language英语
DOI10.1002/mds.28344
Source PublicationMOVEMENT DISORDERS
ISSN0885-3185
Pages10
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[31771216] ; National Natural Science Foundation of China[31961133025] ; National Natural Science Foundation of China[31630034] ; German Research Foundation[SFB TR134 C1] ; Alexander von Humboldt Foundation
PublisherWILEY
WOS KeywordSHORT-TERM-MEMORY ; BRAIN-STIMULATION ; TEMPORAL-ORDER ; BASAL GANGLIA ; SERIAL ORDER ; DOPAMINE ; VALIDITY ; MODEL ; MOTOR ; STN
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology
WOS IDWOS:000581795700001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/33056
Collection健康与遗传心理学研究室
Corresponding AuthorYe, Zheng; Zhang, Yingshuang; Munte, Thomas F.
Affiliation1.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Key Lab Primate Neurobiol, Inst Neurosci, Shanghai, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Peking Univ, Hosp 3, Dept Neurol, North Garden Rd 49, Beijing 100191, Peoples R China
5.Peking Univ, Sch Psychol & Cognit Sci, Ctr Brain & Cognit Sci, Beijing, Peoples R China
6.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing, Peoples R China
7.Univ Lubeck, Dept Neurol, Ratzeburger Allee 160, D-23538 Lubeck, Germany
Recommended Citation
GB/T 7714
Ye, Zheng,Zhang, Guanyu,Zhang, Yingshuang,et al. The Role of the Subthalamic Nucleus in Sequential Working Memory in De Novo Parkinson's Disease[J]. MOVEMENT DISORDERS,2020:10.
APA Ye, Zheng.,Zhang, Guanyu.,Zhang, Yingshuang.,Li, Shuaiqi.,Liu, Na.,...&Munte, Thomas F..(2020).The Role of the Subthalamic Nucleus in Sequential Working Memory in De Novo Parkinson's Disease.MOVEMENT DISORDERS,10.
MLA Ye, Zheng,et al."The Role of the Subthalamic Nucleus in Sequential Working Memory in De Novo Parkinson's Disease".MOVEMENT DISORDERS (2020):10.
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