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Alternative TitleChanges of resting state fMRI brain imaging in patients with depression after antidepressant treatment
崔健1,2; 王赟1,2; 周媛1,2,3,4; 王刚1,2
First Author崔健
Correspondent Emailgangwangdoc@ gmail. com (王刚)
Contribution Rank4


Other Abstract

Antidepressant therapy is effective for patients with major depressive disorder, however the mechanism is unclear and it is difficult to predict the efficacy objectively. At present, the changes of local spontaneous brain activity in patients with major depressive disorder after antidepressant treatment are mostly located in the dorsolateral prefrontal cortex, ventromedial prefrontal cortex, anterior cingulate gyrus and precuneus. The changes of brain function interaction involved in emotional circuit, default mode network, central executive network and hypothalamus-pituitary-adrenal axis. Future researches should optimize the experimental design, enlarge the sample size, reduce the sample heterogeneity, and compare the effects of different types of antidepressants. This paper reviews the effects of antidepressant therapy on brain function in patients with major depressive disorder from the perspective of resting fMRI, to promote our understanding of the mechanism of antidepressant therapy and to promote the discovery of objective biomarkers which can predict the response of antidepressant therapy.

Keyword抑郁症 抗抑郁药物治疗 静息态 功能磁共振成像
DOI10. 3760/cma. j. cn371468-20190523-00335
Source Publication中华行为医学与脑科学杂志
Indexed ByCSCD
Project Intro.

国家重点研发计划(2016YFC1307200 );首都科技领军人才培养工程

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Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
2.首 都医科大学脑保护高精尖创新中心
3.中国科学院心理研究所行为科学 重点实验室
Recommended Citation
GB/T 7714
崔健,王赟,周媛,等. 抗抑郁药物治疗前后抑郁症患者静息态功能磁共振脑影像的变化[J]. 中华行为医学与脑科学杂志,2020,29(2):177-182.
APA 崔健,王赟,周媛,&王刚.(2020).抗抑郁药物治疗前后抑郁症患者静息态功能磁共振脑影像的变化.中华行为医学与脑科学杂志,29(2),177-182.
MLA 崔健,et al."抗抑郁药物治疗前后抑郁症患者静息态功能磁共振脑影像的变化".中华行为医学与脑科学杂志 29.2(2020):177-182.
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