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Alternative TitleCorrelation between Resting- State Voxel- Mirrored Homotopic Connectivity and Cognitive Function in Patients with First-Episode Depression
陈诚1; 王惠玲1; 王高华1; 蒋田仔2; 周媛3; 吴士豪1; 黄欢1; 邹寄林1
First Author陈诚
Contribution Rank3


Other Abstract

Objective: To investigate characteristics and correlation of resting-state voxel-mirrored homotopic connectivity (VMHC) and cognitive function in patients experiencing the initial episode of depression. Methods: Thirty first-episode major depression (MD) patients and 30 normal controls (NC) were enrolled in this study. All subjects underwent resting-state fMRI (rs-fMRI), and the digit symbol test (DST), digit span test (DSPT), and verbal fluency test (VFT) were performed. Routine preprocessing of rs-fMRI data was completed. The rs- fMRI data were analyzed using VMHC. The VMHC values and cognitive function scores of the two groups were compared, and the correlation between the VMHC value and cognitive function scores was analyzed. Results: Compared with the NC group, the MD group showed significantly decreased VMHC values in the bilateral middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG) (P<0.01, AlphaSim correction, voxel number >50). Compared with the NC group, the MD group showed decreased DST, DSPT, and VFT scores (P<0.05). In the MD group, the VMHC value of the bilateral MFG was positively correlated with the DST score (r=0.45, P=0.002), and the VMHC value of the bilateral STG was positively correlated with the DSPT score and VFT score (r=0.32, P=0.01; r=0.34, P=0.02). Conclusion: In patients with first- episode depression, the VMHC value of the bilateral MFG and STG significantly decreases and is closely related to cognitive impairment.

Keyword抑郁症 静息态功能磁共振 脑镜像同伦功能连接 认知功能
Source Publication神经损伤与功能重建
Document Type期刊论文
Recommended Citation
GB/T 7714
陈诚,王惠玲,王高华,等. 首发抑郁症患者静息态脑镜像同伦功能连接与认知功能的相关性研究[J]. 神经损伤与功能重建,2020,15(11):631-634.
APA 陈诚.,王惠玲.,王高华.,蒋田仔.,周媛.,...&邹寄林.(2020).首发抑郁症患者静息态脑镜像同伦功能连接与认知功能的相关性研究.神经损伤与功能重建,15(11),631-634.
MLA 陈诚,et al."首发抑郁症患者静息态脑镜像同伦功能连接与认知功能的相关性研究".神经损伤与功能重建 15.11(2020):631-634.
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