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Effects of Sleep Deprivation on Working Memory: Change in Functional Connectivity Between the Dorsal Attention, Default Mode, and Fronto-Parietal Networks
Dai, Cimin1; Zhang, Ying2; Cai, Xiaoping3; Peng, Ziyi1; Zhang, Liwei4; Shao, Yongcong1,5; Wang, Cuifeng6
First AuthorDai, Cimin
Correspondent Emailbudeshao@aliyun.com (yongcong shao ) ; 15275228256@163.com (cuifeng wang )
Contribution Rank4
Abstract

Sleep deprivation (SD) is very common in modern society and has a profound effect on cognitive function, in particular on working memory (WM). This type of memory is required for completion of many tasks and is adversely affected by SD. However, the cognitive neural mechanism by which SD affects WM, remains unclear. In this study, we investigated the changes in the brain network involved in WM after SD. Twenty-two healthy subjects underwent functional magnetic resonance imaging scan while in a state of resting wakefulness and again after 36 h of total SD and performed a WM task before each scanning session. Nineteen main nodes of the default mode network (DMN), dorsal attention network (DAN), fronto-parietal network (FPN), salience network (SN), and other networks were selected for functional analysis of brain network connections. Functional connectivity measures were computed between seed areas for region of interest (ROI)-to-ROI analysis and to identify patterns of ROI-to-ROI connectivity. The relationship between the significant changes in functional connectivity in the brain network and WM performance were then examined by Pearson's correlation analysis. WM performance declined significantly after SD. Compared with the awake state, the functional connectivity between DAN and DMN significantly increased after SD while that between FPN and DMN significantly decreased. Correlation analysis showed that the enhanced functional connectivity between DAN and DMN was negatively correlated with the decline in WM performance and that the decline in functional connectivity between FPN and DMN was positively correlated with decreased WM performance. These findings suggested that SD may affect WM by altering the functional connectivity among DMN, DAN, and FPN.

Keywordsleep deprivation working memory functional connectivity brain network fMRI
2020-10-12
Language英语
DOI10.3389/fnhum.2020.00360
Source PublicationFRONTIERS IN HUMAN NEUROSCIENCE
ISSN1662-5161
Volume14Pages:12
Subtype实证研究
Indexed BySCI
Funding ProjectNational Science Foundation of Winter Olympics Technology Plan of China[2019YFF0301600] ; National Science and Technology Commission Project[2019JCJQZD119]
PublisherFRONTIERS MEDIA SA
WOS KeywordDORSOLATERAL PREFRONTAL CORTEX ; EVENT-RELATED POTENTIALS ; BRAIN ACTIVITY ; RESTING BRAIN ; METAANALYSIS ; ACTIVATION ; RETRIEVAL ; CINGULATE ; COMPONENT ; DYNAMICS
WOS Research AreaNeurosciences & Neurology ; Psychology
WOS SubjectNeurosciences ; Psychology
WOS IDWOS:000583632100001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/33378
Collection健康与遗传心理学研究室
Corresponding AuthorShao, Yongcong; Wang, Cuifeng
Affiliation1.Beijing Sport Univ, Sch Psychol, Beijing, Peoples R China
2.Gen Hosp Peoples Liberat Army, Med Ctr 8, Beijing, Peoples R China
3.Gen Hosp Peoples Liberat Army, Dept Cadraword, Div 3, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
5.Chinese Acad Sci, Suzhou Inst Biomed Engn & Techol, Suzhou, Peoples R China
6.Qingdao Huangdao Peoples Hosp, Dept Resp Med, Qingdao, Peoples R China
Recommended Citation
GB/T 7714
Dai, Cimin,Zhang, Ying,Cai, Xiaoping,et al. Effects of Sleep Deprivation on Working Memory: Change in Functional Connectivity Between the Dorsal Attention, Default Mode, and Fronto-Parietal Networks[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2020,14:12.
APA Dai, Cimin.,Zhang, Ying.,Cai, Xiaoping.,Peng, Ziyi.,Zhang, Liwei.,...&Wang, Cuifeng.(2020).Effects of Sleep Deprivation on Working Memory: Change in Functional Connectivity Between the Dorsal Attention, Default Mode, and Fronto-Parietal Networks.FRONTIERS IN HUMAN NEUROSCIENCE,14,12.
MLA Dai, Cimin,et al."Effects of Sleep Deprivation on Working Memory: Change in Functional Connectivity Between the Dorsal Attention, Default Mode, and Fronto-Parietal Networks".FRONTIERS IN HUMAN NEUROSCIENCE 14(2020):12.
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