PSYCH OpenIR  > 健康与遗传心理学研究室
The Longitudinal Association Between Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Adults in China: A Nationally Representative Cohort Study
Hua, Wei1; Hou, Jianhua1,2; Jiang, Taiyi1; Su, Bin1,2; Fu, Jiangning3; Sun, Runsong4; Chang, Biru5; Xia, Wei1; Wu, Hao1,2; Zhang, Tong1,2; Guo, Caiping1; Wang, Wen1
First AuthorHua, Wei
Correspondent Emailyouansuid2020@hotmail.com (wen wang ) ; gcpdt001@126.com (caiping guo )
Contribution Rank3
Abstract

Objective: China has the largest population living with dementia, causing a tremendous burden on the aging society. Cardiovascular disease (CVD) may trigger a cascade of pathologies associated with cognitive aging. We aim to investigate the association between cardiovascular risk (CVR) factors and cognitive function in the nationally representative cohort in China. Methods: Participants were recruited from 150 counties in 28 provinces via a four-stage sampling method. The outcomes included several cognitive tasks. The independent variable was a composite score of cardiovascular risk calculated from sex-specific equations. We fitted the time-lagged regression to model the association between CVR and cognition. Besides, we performed cross-group analyses to test for model invariance across sex and age. We thus constrained path coefficients to be equal across each grouping variable (e.g., sex) and compared the fit of this constrained model with an unconstrained model in which the path coefficients were allowed to vary by group. Results: A total of 3,799 participants were included in the final analyses. We found that the CVR had a negative linear association with global cognition (beta = -0.1, p < 0.01). Additionally, CVR had inverse linear associations with domain-specific measurements of memory and learning, calculation, orientation, and visual-spatial ability (all values of p < 0.01). Regarding sex and age moderation, males had a more pronounced association between higher CVR and worse general cognition, immediate recall, orientation, calculation, and visual-spatial ability (all values of p < 0.0001). In contrast, females exhibited a slightly larger negative association in delayed recall. Older participants (>65 years old) had a more pronounced association between higher CVR and worse calculation ability (p = 0.003). Conclusion: CVD are risk factors for lower global cognition and cognitive subdomains in middle-aged and older adults in China.

Keywordcardiovascular risk cognition longitudinal study older adult national representative data set
2020-10-19
DOI10.3389/fcvm.2020.560947
Source PublicationFRONTIERS IN CARDIOVASCULAR MEDICINE
ISSN2297-055X
Volume7Pages:11
Subtype实证研究
Indexed BySCI
Funding ProjectNational 13th 5-Year Grand Program on Key Infectious Disease Control[2018ZX10715-005-002-002] ; National 13th 5-Year Grand Program on Key Infectious Disease Control[2017ZX10202101-001-004] ; National 13th 5-Year Grand Program on Key Infectious Disease Control[2017ZX10202101-004-001] ; National 13th 5-Year Grand Program on Key Infectious Disease Control[2018ZX10301-407-005] ; National 13th 5-Year Grand Program on Key Infectious Disease Control[2018ZX10302103-001-003] ; Beijing Municipal of Science and Technology Major Project[D161100000416003] ; Beijing Municipal of Science and Technology Major Project[D161100000416005] ; Key Laboratory of Capital Medical University[BJYAHKF2017002] ; Beijing Key Laboratory for HIV/AIDS Research[BZ0089]
PublisherFRONTIERS MEDIA SA
WOS KeywordNORTHERN MANHATTAN ; SEX-DIFFERENCES ; DECLINE ; HYPERTENSION ; PREVALENCE ; DEMENTIA ; PROFILE ; TRAJECTORIES ; POPULATION ; MEMORY
WOS Research AreaCardiovascular System & Cardiology
WOS SubjectCardiac & Cardiovascular Systems
WOS IDWOS:000583254800001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/33381
Collection健康与遗传心理学研究室
Corresponding AuthorGuo, Caiping; Wang, Wen
Affiliation1.Capital Med Univ, Beijing Youan Hosp, Ctr Infect Dis, Beijing, Peoples R China
2.Beijing Key Lab HIV AIDS Res, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
4.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
5.Shanghai Normal Univ, Res Inst Int & Comparat Educ, Dept Psychol, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Hua, Wei,Hou, Jianhua,Jiang, Taiyi,et al. The Longitudinal Association Between Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Adults in China: A Nationally Representative Cohort Study[J]. FRONTIERS IN CARDIOVASCULAR MEDICINE,2020,7:11.
APA Hua, Wei.,Hou, Jianhua.,Jiang, Taiyi.,Su, Bin.,Fu, Jiangning.,...&Wang, Wen.(2020).The Longitudinal Association Between Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Adults in China: A Nationally Representative Cohort Study.FRONTIERS IN CARDIOVASCULAR MEDICINE,7,11.
MLA Hua, Wei,et al."The Longitudinal Association Between Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Adults in China: A Nationally Representative Cohort Study".FRONTIERS IN CARDIOVASCULAR MEDICINE 7(2020):11.
Files in This Item:
File Name/Size DocType Version Access License
The Longitudinal Ass(1542KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hua, Wei]'s Articles
[Hou, Jianhua]'s Articles
[Jiang, Taiyi]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hua, Wei]'s Articles
[Hou, Jianhua]'s Articles
[Jiang, Taiyi]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hua, Wei]'s Articles
[Hou, Jianhua]'s Articles
[Jiang, Taiyi]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.