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Prevalence of obesity and clinical and metabolic correlates in first-episode schizophrenia relative to healthy controls
Tian, Yang1,2; Wang, Dongmei1,2; Wei, Gaoxia1,2; Wang, Jiesi1,2; Zhou, Huixia1,2; Xu, Hang1,2; Dai, Qilong1,2; Xiu, Meihong3; Chen, Dachun3; Wang, Li1,2; Zhang, Xiang Yang1,2
第一作者Tian, Yang
通讯作者邮箱zhangxy@psych.ac.cn (xiang yang zhang)
心理所单位排序1
摘要

Objective People with schizophrenia exhibit a high obesity rate. However, little is known about the prevalence of obesity and its relationship with clinical symptoms and metabolic indicators in first-episode drug-naive (FEDN) schizophrenia. Methods Demographic and lipid parameters were gathered from 297 FEDN schizophrenia and 325 healthy controls. The patients' symptomatology was evaluated by the Positive and Negative Syndrome Scale (PANSS). Results The obesity rate of FEDN patients was 10.77%, similar to that of controls (10.5%). The prevalence of overweight plus obesity of patients was 44.8%, significantly higher than that of controls (36.6%). Compared with non-obese patients, obese patients had higher levels of cholesterol (4.81 +/- 0.93 vs 4.22 +/- 1.00 mmol/L), triglyceride (0.27 +/- 0.21 vs 0.14 +/- 0.24 mg/dL), low-density lipoprotein (0.48 +/- 0.12 vs 0.40 +/- 0.12 mg/dL), greater ratio of triglyceride/high-density lipoprotein (2.01 +/- 1.23 vs 1.44 +/- 1.26), and higher PANSS positive symptom subscale score (29.81 +/- 6.29 vs 27.05 +/- 6.15), general psychopathology subscale score (70.75 +/- 11.74 vs 66.87 +/- 11.37), and total score (149.81 +/- 21.08 vs 140.64 +/- 21.58), but lower high-density lipoprotein level (1.09 +/- 0.21 vs 1.27 +/- 0.34 mg/dL) (all p < 0.05). Correlation analysis revealed that body mass index (BMI) was positively correlated with triglyceride, cholesterol, high-density lipoprotein, low-density lipoprotein, triglyceride/high-density lipoprotein ratio, PANSS positive symptoms, general psychopathology, and total scores (all p < 0.05, r = 0.124 similar to 0.335). Multiple regression analysis confirmed that PANSS positive symptoms, total score, and cholesterol level were significantly associated with BMI (all p < 0.05, beta: 0.126-0.162). Conclusion There was no significant difference in the prevalence of obesity between FEDN patients and the control group. Moreover, BMI was positively associated with positive symptom severity in FEDN patients.

关键词First-episode drug-naive with schizophrenia Clinical symptom Obesity Body mass index
2020-11-25
DOI10.1007/s00213-020-05727-1
发表期刊PSYCHOPHARMACOLOGY
ISSN0033-3158
卷号238期号:3页码:745-753
期刊论文类型实证研究
收录类别SCI
资助项目CAS Pioneer Hundred Talents Program ; National Natural Science Foundation of China[81371477]
出版者SPRINGER
WOS关键词INDUCED WEIGHT-GAIN ; DRUG-FREE PATIENTS ; BODY-MASS INDEX ; INSULIN-RESISTANCE ; CHINESE PATIENTS ; SELF-ESTEEM ; FOOD-INTAKE ; NAIVE ; DYSLIPIDEMIA ; MECHANISMS
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000592578300004
WOS分区Q2
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/33442
专题中国科学院心理健康重点实验室
通讯作者Zhang, Xiang Yang
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China
第一作者单位中国科学院心理健康重点实验室
通讯作者单位中国科学院心理健康重点实验室
推荐引用方式
GB/T 7714
Tian, Yang,Wang, Dongmei,Wei, Gaoxia,et al. Prevalence of obesity and clinical and metabolic correlates in first-episode schizophrenia relative to healthy controls[J]. PSYCHOPHARMACOLOGY,2020,238(3):745-753.
APA Tian, Yang.,Wang, Dongmei.,Wei, Gaoxia.,Wang, Jiesi.,Zhou, Huixia.,...&Zhang, Xiang Yang.(2020).Prevalence of obesity and clinical and metabolic correlates in first-episode schizophrenia relative to healthy controls.PSYCHOPHARMACOLOGY,238(3),745-753.
MLA Tian, Yang,et al."Prevalence of obesity and clinical and metabolic correlates in first-episode schizophrenia relative to healthy controls".PSYCHOPHARMACOLOGY 238.3(2020):745-753.
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