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Prevalence of obesity and clinical and metabolic correlates in first-episode schizophrenia relative to healthy controls
Tian, Yang1,2; Wang, Dongmei1,2; Wei, Gaoxia1,2; Wang, Jiesi1,2; Zhou, Huixia1,2; Xu, Hang1,2; Dai, Qilong1,2; Xiu, Meihong3; Chen, Dachun3; Wang, Li1,2; Zhang, Xiang Yang1,2
First AuthorTian, Yang
Correspondent Emailzhangxy@psych.ac.cn (xiang yang zhang)
Contribution Rank1
Abstract

Objective People with schizophrenia exhibit a high obesity rate. However, little is known about the prevalence of obesity and its relationship with clinical symptoms and metabolic indicators in first-episode drug-naive (FEDN) schizophrenia. Methods Demographic and lipid parameters were gathered from 297 FEDN schizophrenia and 325 healthy controls. The patients' symptomatology was evaluated by the Positive and Negative Syndrome Scale (PANSS). Results The obesity rate of FEDN patients was 10.77%, similar to that of controls (10.5%). The prevalence of overweight plus obesity of patients was 44.8%, significantly higher than that of controls (36.6%). Compared with non-obese patients, obese patients had higher levels of cholesterol (4.81 +/- 0.93 vs 4.22 +/- 1.00 mmol/L), triglyceride (0.27 +/- 0.21 vs 0.14 +/- 0.24 mg/dL), low-density lipoprotein (0.48 +/- 0.12 vs 0.40 +/- 0.12 mg/dL), greater ratio of triglyceride/high-density lipoprotein (2.01 +/- 1.23 vs 1.44 +/- 1.26), and higher PANSS positive symptom subscale score (29.81 +/- 6.29 vs 27.05 +/- 6.15), general psychopathology subscale score (70.75 +/- 11.74 vs 66.87 +/- 11.37), and total score (149.81 +/- 21.08 vs 140.64 +/- 21.58), but lower high-density lipoprotein level (1.09 +/- 0.21 vs 1.27 +/- 0.34 mg/dL) (all p < 0.05). Correlation analysis revealed that body mass index (BMI) was positively correlated with triglyceride, cholesterol, high-density lipoprotein, low-density lipoprotein, triglyceride/high-density lipoprotein ratio, PANSS positive symptoms, general psychopathology, and total scores (all p < 0.05, r = 0.124 similar to 0.335). Multiple regression analysis confirmed that PANSS positive symptoms, total score, and cholesterol level were significantly associated with BMI (all p < 0.05, beta: 0.126-0.162). Conclusion There was no significant difference in the prevalence of obesity between FEDN patients and the control group. Moreover, BMI was positively associated with positive symptom severity in FEDN patients.

KeywordFirst-episode drug-naive with schizophrenia Clinical symptom Obesity Body mass index
2020-11-25
Language英语
DOI10.1007/s00213-020-05727-1
Source PublicationPSYCHOPHARMACOLOGY
ISSN0033-3158
Pages9
Subtype实证研究
Indexed BySCI
Funding ProjectCAS Pioneer Hundred Talents Program ; National Natural Science Foundation of China[81371477]
PublisherSPRINGER
WOS KeywordINDUCED WEIGHT-GAIN ; DRUG-FREE PATIENTS ; BODY-MASS INDEX ; INSULIN-RESISTANCE ; CHINESE PATIENTS ; SELF-ESTEEM ; FOOD-INTAKE ; NAIVE ; DYSLIPIDEMIA ; MECHANISMS
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectNeurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000592578300004
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/33442
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Xiang Yang
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Tian, Yang,Wang, Dongmei,Wei, Gaoxia,et al. Prevalence of obesity and clinical and metabolic correlates in first-episode schizophrenia relative to healthy controls[J]. PSYCHOPHARMACOLOGY,2020:9.
APA Tian, Yang.,Wang, Dongmei.,Wei, Gaoxia.,Wang, Jiesi.,Zhou, Huixia.,...&Zhang, Xiang Yang.(2020).Prevalence of obesity and clinical and metabolic correlates in first-episode schizophrenia relative to healthy controls.PSYCHOPHARMACOLOGY,9.
MLA Tian, Yang,et al."Prevalence of obesity and clinical and metabolic correlates in first-episode schizophrenia relative to healthy controls".PSYCHOPHARMACOLOGY (2020):9.
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