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Cognitive Enhancing Effect of High-Frequency Neuronavigated rTMS in Chronic Schizophrenia Patients With Predominant Negative Symptoms: A Double-Blind Controlled 32-Week Follow-up Study
Xiu, Mei Hong1; Guan, Heng Yong2; Zhao, Jian Min2; Wang, Ke Qiang2; Pan, Yan Fen2; Su, Xiu Ru2; Wang, Yu Hong2; Guo, Jin Ming2; Jiang, Long2; Liu, Hong Yu2; Sun, Shi Guang2; Wu, Hao Ran2; Geng, Han Song2; Liu, Xiao Wen2; Yu, Hui Jing2; Wei, Bao Chun2; Li, Xi Po2; Trinh, Tammy3; Tan, Shu Ping1; Zhang, Xiang Yang4,5
First AuthorXiu, Mei Hong
Correspondent Emailzhangxy@psych.ac.cn (xiang yang zhang )
Abstract

Accumulating studies have shown that high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) may improve cognitive dysfunction of the patients with schizophrenia (SCZ), but with inconsistent results. The present study aims to assess the efficacy of different frequencies of neuronavigated rTMS in ameliorating cognitive impairments and alleviating the psychotic symptoms. A total of 120 patients were randomly assigned to 3 groups: 20 Hz rTMS (n = 40), 10 Hz rTMS (n = 40), or sham stimulation (n = 40) for 8 weeks, and then followed up at week 32. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was performed to assess the cognitive functions of the patients at baseline, at the end of week 8, and week 32 follow-up. Psychotic symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS) at baseline and at the end of week 2, week 4, week 6, week 8, and week 32 follow-up. Our results demonstrated that 20 Hz rTMS treatment produced an effective therapeutic benefit on immediate memory of patients with chronic SCZ at week 8, but not in the 10 Hz group. Interestingly, both 10 Hz and 20 Hz rTMS treatments produced delayed effects on cognitive functions at the 6-month follow-up. Moreover, in both 10 Hz rTMS and 20 Hz rTMS, the improvements in RBANS total score were positively correlated with the reduction of PANSS positive subscore at the 6-month follow-up. Stepwise regression analysis identified that the visuospatial/constructional index, immediate memory index, and prolactin at baseline were predictors for the improvement of cognitive impairments in the patients. Our results suggest that add-on HF rTMS could be an effective treatment for cognitive impairments in patients with chronic SCZ, with a delayed effect.

Keywordschizophrenia cognition rTMS randomized controlled trial immediate memory
2020-09-01
DOI10.1093/schbul/sbaa035
Source PublicationSCHIZOPHRENIA BULLETIN
ISSN0586-7614
Volume46Issue:5Pages:1219-1230
Subtype实证研究
Indexed BySCI
Funding ProjectScientific and Technological Program of Hebei[20150593]
PublisherOXFORD UNIV PRESS
WOS KeywordTRANSCRANIAL MAGNETIC STIMULATION ; DORSOLATERAL PREFRONTAL CORTEX ; BRAIN-STIMULATION ; METAANALYSIS ; EFFICACY ; REMEDIATION ; PROLACTIN ; DOPAMINE ; TMS
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000593174100024
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/33448
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Xiang Yang
Affiliation1.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China
2.Hebei Prov Rong Jun Hosp, Dept Psychiat, Baoding, Peoples R China
3.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Xiu, Mei Hong,Guan, Heng Yong,Zhao, Jian Min,et al. Cognitive Enhancing Effect of High-Frequency Neuronavigated rTMS in Chronic Schizophrenia Patients With Predominant Negative Symptoms: A Double-Blind Controlled 32-Week Follow-up Study[J]. SCHIZOPHRENIA BULLETIN,2020,46(5):1219-1230.
APA Xiu, Mei Hong.,Guan, Heng Yong.,Zhao, Jian Min.,Wang, Ke Qiang.,Pan, Yan Fen.,...&Zhang, Xiang Yang.(2020).Cognitive Enhancing Effect of High-Frequency Neuronavigated rTMS in Chronic Schizophrenia Patients With Predominant Negative Symptoms: A Double-Blind Controlled 32-Week Follow-up Study.SCHIZOPHRENIA BULLETIN,46(5),1219-1230.
MLA Xiu, Mei Hong,et al."Cognitive Enhancing Effect of High-Frequency Neuronavigated rTMS in Chronic Schizophrenia Patients With Predominant Negative Symptoms: A Double-Blind Controlled 32-Week Follow-up Study".SCHIZOPHRENIA BULLETIN 46.5(2020):1219-1230.
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