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Sex-specific association between peripheral superoxide dismutase, BDNF and cognitive impairment in drug-naive first episode patients with schizophrenia
Qu, Miao1; Wang, Jun2; Chen, Chun2; Chen, Song2; Xiu, Mei Hong2; Zhang, Xiang Yang3,4
First AuthorQu, Miao
Correspondent Emailxiumeihong97@163.com (m.h. xiu) ; zhangxy@psych.ac.cn (x.y. zhang)
Contribution Rank3
Abstract

Patients with schizophrenia (SCZ) have cognitive impairments across several domains. Cognition decline is related to the complex interrelationship between brain-derived neurotrophic factor (BDNF) and redox system imbalance. However, the effect of sex on cognitive impairment and biomarkers has not been fully studied in patients with drug-naive first episode (DNFE) SCZ. 327 DNFE SCZ patients and 391 healthy controls were recruited, and the levels of BDNF and malondialdehyde (MDA) and the activities of total SOD, Mn-SOD, CuZn-SOD enzymes were measured. Cognitive function was measured by using the Repeatable Battery for the Assessment of Neuropsychological status (RBANS) and clinical symptoms by the Positive and Negative Syndrome Scale (PANSS). Patients performed worse on most cognitive tasks than controls, but there was no significant sex difference in cognitive function between patients and controls. Further analysis showed that a sex difference in MDA was found in controls rather than patients, indicating that MDA levels in men were higher than those in women in controls. Moreover, the Mn-SOD was significantly correlated with attention, language and RBANS total scores only in male patients. Multiple linear regression analysis showed that the interaction between BDNF and Mn-SOD or SOD was associated with RBANS language index score in male patients. Our results suggest that the interrelationship of BDNF with antioxidant mechanisms may contribute to the pathological mechanisms underlying cognitive deficits only in male DNFE patients with SCZ, but not in female patients.

KeywordSchizophrenia BDNF Superoxide dismutase Sex difference Cognitive function
2020-11-20
Language英语
DOI10.1016/j.freeradbiomed.2020.09.014
Source PublicationFREE RADICAL BIOLOGY AND MEDICINE
ISSN0891-5849
Volume160Pages:887-893
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81973759] ; National Natural Science Foundation of China[81000509] ; National Natural Science Foundation of China[10400633210001]
PublisherELSEVIER SCIENCE INC
WOS KeywordNEGATIVE SYNDROME SCALE ; OXIDATIVE STRESS ; GENDER-DIFFERENCE ; FATTY-ACID ; PLASMA ; BRAIN ; MITOCHONDRIA ; TESTOSTERONE ; POLYMORPHISM ; SYMPTOMS
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS IDWOS:000595084100003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/33451
Collection中国科学院心理健康重点实验室
Corresponding AuthorXiu, Mei Hong; Zhang, Xiang Yang
Affiliation1.Capital Med Univ, Neurol Dept, Xuan Wu Hosp, Beijing, Peoples R China
2.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Qu, Miao,Wang, Jun,Chen, Chun,et al. Sex-specific association between peripheral superoxide dismutase, BDNF and cognitive impairment in drug-naive first episode patients with schizophrenia[J]. FREE RADICAL BIOLOGY AND MEDICINE,2020,160:887-893.
APA Qu, Miao,Wang, Jun,Chen, Chun,Chen, Song,Xiu, Mei Hong,&Zhang, Xiang Yang.(2020).Sex-specific association between peripheral superoxide dismutase, BDNF and cognitive impairment in drug-naive first episode patients with schizophrenia.FREE RADICAL BIOLOGY AND MEDICINE,160,887-893.
MLA Qu, Miao,et al."Sex-specific association between peripheral superoxide dismutase, BDNF and cognitive impairment in drug-naive first episode patients with schizophrenia".FREE RADICAL BIOLOGY AND MEDICINE 160(2020):887-893.
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