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Oxytocin effects on the resting-state mentalizing brain network
Wu, Haiyan1,2,3; Feng, Chunliang4; Lu, Xiaping4; Liu, Xun1,2; Liu, Quanying5,6,7
First AuthorWu, Haiyan
Correspondent Emailliuqy@sustech.edu.cn (quanying liu)
Contribution Rank1
Abstract

Oxytocin (OT) has modulatory effects in both human behavior and in the brain, which is not limited in the specific brain area but also with the potential effect on connectivity with other brain regions. Evidence indicates that OT effects on human behavior are multifaceted, such as trust behavior, decrease anxiety, empathy and bonding behavior. For the vital role of mentalizing in understanding others, here we examine whether OT has a general effect on mentalizing brain network which is associated to the effect of related social behavioral and personality traits. Using a randomized, double-blind placebo-controlled group design, we investigate the resting-state functional magnetic resonance imaging after intranasal OT or placebo. The functional connectivity (FC) maps with seed in left/right temporoparietal junction (lTPJ/rTPJ) showed that OT significantly increased connectivity between rTPJ and default attention network (DAN), but decreased the FC between lTPJ and medial prefrontal network (MPN). With machine learning approach, we report that identified altered FCs of TPJ can classify OT and placebo (PL) group. Moreover, individual's empathy trait can modulate the FC between left TPJ and right rectus (RECT), which shows a positive correlation with empathic concern in PL group but a negative correlation in OT group. These results demonstrate that OT has significant effect on FC with lTPJ and rTPJ, brain regions where are critical for mentalizing, and the empathy concern can modulate the FC. These findings advance our understanding of the neural mechanisms by which OT modulates social behaviors, especially in social interaction involving mentalizing.

KeywordOxytocin Functional connectivity fMRI Temporoparietal junction Mentalizing network
2020-12-01
DOI10.1007/s11682-019-00205-5
Source PublicationBRAIN IMAGING AND BEHAVIOR
ISSN1931-7557
Volume14Issue:6Pages:2530-2541
Subtype实证研究
Indexed BySCI
PublisherSPRINGER
WOS KeywordTEMPORO-PARIETAL JUNCTION ; FUNCTIONAL CONNECTIVITY ; INTRANASAL OXYTOCIN ; SOCIAL COGNITION ; TEMPOROPARIETAL JUNCTION ; EMOTION RECOGNITION ; DEFAULT MODE ; AMYGDALA ; EMPATHY ; FMRI
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000587138100038
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/33458
Collection中国科学院行为科学重点实验室
Corresponding AuthorLiu, Quanying
Affiliation1.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.CALTECH, Div Humanities & Social Sci, Pasadena, CA 91125 USA
4.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
5.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen, Peoples R China
6.CALTECH, Div Engn & Appl Sci, Pasadena, CA 91125 USA
7.Huntington Med Res Inst, Neurosci, Pasadena, CA 91105 USA
First Author AffilicationKey Laboratory of Behavioral Science, CAS
Recommended Citation
GB/T 7714
Wu, Haiyan,Feng, Chunliang,Lu, Xiaping,et al. Oxytocin effects on the resting-state mentalizing brain network[J]. BRAIN IMAGING AND BEHAVIOR,2020,14(6):2530-2541.
APA Wu, Haiyan,Feng, Chunliang,Lu, Xiaping,Liu, Xun,&Liu, Quanying.(2020).Oxytocin effects on the resting-state mentalizing brain network.BRAIN IMAGING AND BEHAVIOR,14(6),2530-2541.
MLA Wu, Haiyan,et al."Oxytocin effects on the resting-state mentalizing brain network".BRAIN IMAGING AND BEHAVIOR 14.6(2020):2530-2541.
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