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Cognitive deficits and white matter abnormalities in never-treated first-episode schizophrenia
Yang, Mi1,2,3; Gao, Shan1; Zhang, Xiangyang4,5
First AuthorYang, Mi
Correspondent Emailgaoshan@uestc.edu.cn (shan gao) ; zhangxy@psych.ac.cn (xiangyang zhang)
Contribution Rank4
Abstract

Cognitive impairment is viewed as a core symptom of schizophrenia (SCZ), but its pathophysiological mechanism remains unclear. White matter (WM) disruption is considered to be a central abnormality that may contribute to cognitive impairment in SCZ patients. However, few studies have addressed the association between cognition and WM integrity in never-treated first-episode (NTFE) patients with SCZ. In this study, we used the MATRICS Consensus Cognitive Battery (MCCB) to evaluate cognitive function in NTFE patients (n=39) and healthy controls (n=30), and associated it with whole-brain fractional anisotropy (FA) values obtained via voxel-based diffusion tensor imaging. We found that FA was lower in five brain areas of SCZ patients, including the cingulate gyrus, internal capsule, corpus callosum, cerebellum, and brainstem. Compared with the healthy control group, the MCCB's total score and 8 out of 10 subscores were significantly lower in NTFE patients (all p<0.001). Moreover, in patients but not healthy controls, the performance in the Trail Making Test was negatively correlated with the FA value in the left cingulate. Our findings provide evidence that WM disconnection is involved in some cognitive impairment in the early course of SCZ.

2020-11-02
DOI10.1038/s41398-020-01049-0
Source PublicationTRANSLATIONAL PSYCHIATRY
ISSN2158-3188
Volume10Issue:1Pages:8
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[61806042] ; National Natural Science Foundation of China[31600880]
PublisherSPRINGERNATURE
WOS KeywordDIFFUSION TENSOR ; FRACTIONAL ANISOTROPY ; WORKING-MEMORY ; STRUCTURAL CONNECTIVITY ; INTEGRITY ; MICROSTRUCTURE ; IMPAIRMENT ; SYMPTOMS ; DISORDER ; BATTERY
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000589695200003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/33461
Collection中国科学院心理健康重点实验室
Corresponding AuthorGao, Shan; Zhang, Xiangyang
Affiliation1.Univ Elect Sci & Technol China, Key Lab NeuroInformat, MOE, Chengdu Brain Sci Inst,Clin Hosp, Chengdu, Peoples R China
2.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu, Peoples R China
3.Fourth Peoples Hosp Chengdu, Chengdu, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Yang, Mi,Gao, Shan,Zhang, Xiangyang. Cognitive deficits and white matter abnormalities in never-treated first-episode schizophrenia[J]. TRANSLATIONAL PSYCHIATRY,2020,10(1):8.
APA Yang, Mi,Gao, Shan,&Zhang, Xiangyang.(2020).Cognitive deficits and white matter abnormalities in never-treated first-episode schizophrenia.TRANSLATIONAL PSYCHIATRY,10(1),8.
MLA Yang, Mi,et al."Cognitive deficits and white matter abnormalities in never-treated first-episode schizophrenia".TRANSLATIONAL PSYCHIATRY 10.1(2020):8.
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