Institutional Repository of Key Laboratory of Mental Health, CAS
Altered default mode network functional connectivity in individuals with co-occurrence of schizotypy and obsessive-compulsive traits | |
Wang, Yong-ming1,2,3,4; Cai, Xin-lu1,2,3,4; Zhou, Han-yu1,4; Zhang, Rui-ting1,4; Zhang, Yi-jing1,4; Wang, Yan-yu1,4; Cheung, Eric F. C.5; Chan, Raymond C. K.1,2,3,4 | |
第一作者 | Wang, Yong-ming |
通讯作者邮箱 | rckchan@psych.ac.cn (r.c.k. chan) |
心理所单位排序 | 1 |
摘要 | In this study, we examined differences in resting-state functional connectivity between sub-regions of the Default Mode Network (DMN) and whole brain voxels in 22 individuals with high schizo-obsessive traits (SOT), 30 with high schizotypal traits (SCT) alone, 20 with high obsessive-compulsive traits (OCT) alone and 30 with low trait scores (LT). We found that the SOT group showed the most reduced functional connectivity within the DMN compared with the other groups. The SOT group also showed increased connectivity between the DMN and the Salience Network, and between the DMN and the Auditory Network compared with the LT group. The SCT group exhibited increased connectivity between the DMN and the Salience Network, and between the DMN and the Executive Control Network (ECN) compared with the LT group. The OCT group exhibited decreased connectivity within the DMN, between the DMN and the Salience Network, and between the DMN and the ECN compared with the LT group. These findings highlight different changes in DMN-related functional connectivity associated with high SOT, SCT and OCT traits and may provide insight into the dysfunctional brain networks in the early stage of schizophrenia spectrum disorders. |
关键词 | Schizo-obsessive traits Schizotypal traits Obsessive-compulsive traits Functional connectivity Default mode network |
2020-11-30 | |
DOI | 10.1016/j.pscychresns.2020.111170 |
发表期刊 | PSYCHIATRY RESEARCH-NEUROIMAGING |
ISSN | 0925-4927 |
卷号 | 305页码:9 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; Chinese Academy of Science[XDB02030002] ; CAS Key Laboratory of Mental Health, Institute of Psychology |
出版者 | ELSEVIER IRELAND LTD |
WOS关键词 | RESTING-STATE ; PERSONALITY-TRAITS ; SALIENCE NETWORK ; SCHIZOPHRENIA ; DISORDER ; PSYCHOSIS ; SYMPTOMS ; DISINTEGRATION ; SYMPTOMATOLOGY ; DYSCONNECTION |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Clinical Neurology ; Neuroimaging ; Psychiatry |
WOS记录号 | WOS:000581591900005 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/33467 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Chan, Raymond C. K. |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Sino Danish Coll, Beijing 100190, Peoples R China 3.Sino Danish Ctr Educ & Res, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Castle Peak Hosp, Hong Kong, Peoples R China |
第一作者单位 | 认知与发展心理学研究室 |
通讯作者单位 | 认知与发展心理学研究室 |
推荐引用方式 GB/T 7714 | Wang, Yong-ming,Cai, Xin-lu,Zhou, Han-yu,et al. Altered default mode network functional connectivity in individuals with co-occurrence of schizotypy and obsessive-compulsive traits[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2020,305:9. |
APA | Wang, Yong-ming.,Cai, Xin-lu.,Zhou, Han-yu.,Zhang, Rui-ting.,Zhang, Yi-jing.,...&Chan, Raymond C. K..(2020).Altered default mode network functional connectivity in individuals with co-occurrence of schizotypy and obsessive-compulsive traits.PSYCHIATRY RESEARCH-NEUROIMAGING,305,9. |
MLA | Wang, Yong-ming,et al."Altered default mode network functional connectivity in individuals with co-occurrence of schizotypy and obsessive-compulsive traits".PSYCHIATRY RESEARCH-NEUROIMAGING 305(2020):9. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Altered default mode(798KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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