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Altered default mode network functional connectivity in individuals with co-occurrence of schizotypy and obsessive-compulsive traits
Wang, Yong-ming1,2,3,4; Cai, Xin-lu1,2,3,4; Zhou, Han-yu1,4; Zhang, Rui-ting1,4; Zhang, Yi-jing1,4; Wang, Yan-yu1,4; Cheung, Eric F. C.5; Chan, Raymond C. K.1,2,3,4
First AuthorWang, Yong-ming
Correspondent Emailrckchan@psych.ac.cn (r.c.k. chan)
Contribution Rank1
Abstract

In this study, we examined differences in resting-state functional connectivity between sub-regions of the Default Mode Network (DMN) and whole brain voxels in 22 individuals with high schizo-obsessive traits (SOT), 30 with high schizotypal traits (SCT) alone, 20 with high obsessive-compulsive traits (OCT) alone and 30 with low trait scores (LT). We found that the SOT group showed the most reduced functional connectivity within the DMN compared with the other groups. The SOT group also showed increased connectivity between the DMN and the Salience Network, and between the DMN and the Auditory Network compared with the LT group. The SCT group exhibited increased connectivity between the DMN and the Salience Network, and between the DMN and the Executive Control Network (ECN) compared with the LT group. The OCT group exhibited decreased connectivity within the DMN, between the DMN and the Salience Network, and between the DMN and the ECN compared with the LT group. These findings highlight different changes in DMN-related functional connectivity associated with high SOT, SCT and OCT traits and may provide insight into the dysfunctional brain networks in the early stage of schizophrenia spectrum disorders.

KeywordSchizo-obsessive traits Schizotypal traits Obsessive-compulsive traits Functional connectivity Default mode network
2020-11-30
DOI10.1016/j.pscychresns.2020.111170
Source PublicationPSYCHIATRY RESEARCH-NEUROIMAGING
ISSN0925-4927
Volume305Pages:9
Subtype实证研究
Indexed BySCI
Funding ProjectNational Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; Chinese Academy of Science[XDB02030002] ; CAS Key Laboratory of Mental Health, Institute of Psychology
PublisherELSEVIER IRELAND LTD
WOS KeywordRESTING-STATE ; PERSONALITY-TRAITS ; SALIENCE NETWORK ; SCHIZOPHRENIA ; DISORDER ; PSYCHOSIS ; SYMPTOMS ; DISINTEGRATION ; SYMPTOMATOLOGY ; DYSCONNECTION
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Neuroimaging ; Psychiatry
WOS IDWOS:000581591900005
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/33467
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Sino Danish Coll, Beijing 100190, Peoples R China
3.Sino Danish Ctr Educ & Res, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Castle Peak Hosp, Hong Kong, Peoples R China
First Author Affilication认知与发展心理学研究室
Corresponding Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Wang, Yong-ming,Cai, Xin-lu,Zhou, Han-yu,et al. Altered default mode network functional connectivity in individuals with co-occurrence of schizotypy and obsessive-compulsive traits[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2020,305:9.
APA Wang, Yong-ming.,Cai, Xin-lu.,Zhou, Han-yu.,Zhang, Rui-ting.,Zhang, Yi-jing.,...&Chan, Raymond C. K..(2020).Altered default mode network functional connectivity in individuals with co-occurrence of schizotypy and obsessive-compulsive traits.PSYCHIATRY RESEARCH-NEUROIMAGING,305,9.
MLA Wang, Yong-ming,et al."Altered default mode network functional connectivity in individuals with co-occurrence of schizotypy and obsessive-compulsive traits".PSYCHIATRY RESEARCH-NEUROIMAGING 305(2020):9.
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