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Supraspinal neural mechanisms of the analgesic effect produced by transcutaneous electrical nerve stimulation
Bi, Yanzhi1,2; Wei, Zhaoxing2,3; Kong, Yazhuo2,3; Hu, Li1,2,4
First AuthorBi, Yanzhi
Correspondent Emailhuli@psych.ac.cn (li hu)
Contribution Rank1
Abstract

Although the analgesic effects of conventional transcutaneous electrical nerve stimulation (TENS) and acupuncture-like TENS are evident, their respective neural mechanisms in humans remain controversial. To elucidate and compare the supraspinal neural mechanisms of the analgesic effects produced by conventional TENS (high frequency and low intensity) and acupuncture-like TENS (low frequency and high intensity), we employed a between-subject sham-controlled experimental design with conventional, acupuncture-like, and sham TENS in 60 healthy human volunteers. In addition to assessing the TENS-induced changes of subjective ratings of perceived pain, we examined the TENS associated brainstem activities (fractional amplitude of low frequency fluctuations, fALFF) and their corresponding resting state functional connectivity (RSFC) with higher-order brain areas using functional magnetic resonance imaging. The analgesic effect of conventional TENS was only detected in the forearm that received TENS, coupled with decreased pons activity and RSFC between pons and contralateral primary somatosensory cortex. In contrast, acupuncture-like TENS produced a spatially diffuse analgesic effect, coupled with increased activities in both subnucleus reticularis dorsalis (SRD) and rostral ventromedial medulla (RVM), and decreased RSFC between SRD and medial frontal regions as well as between SRD and lingual gyrus. To sum up, our data demonstrated that conventional TENS and acupuncture-like TENS have different analgesic effects, which are mediated by different supraspinal neural mechanisms.

KeywordTranscutaneous electrical nerve stimulation (TENS) Pain Functional magnetic resonance imaging (fMRI) Analgesic effect Subnucleus reticularis dorsalis (SRD) Rostral ventromedial medulla (RVM)
2020-11-24
Language英语
DOI10.1007/s00429-020-02173-9
Source PublicationBRAIN STRUCTURE & FUNCTION
ISSN1863-2653
Pages12
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[31800926] ; National Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[31671141] ; China Postdoctoral Science Foundation[2018M640191] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y8CX351005] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y6CX021008] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2018ZG01] ; Magnetic Resonance Imaging Research Center, Institute of Psychology, CAS
PublisherSPRINGER HEIDELBERG
WOS KeywordCONDITIONED PAIN MODULATION ; NOXIOUS INHIBITORY CONTROLS ; SUBNUCLEUS-RETICULARIS-DORSALIS ; RESTING-STATE ; OPIOID RECEPTORS ; LOW-FREQUENCY ; INVOLVEMENT ; FMRI ; PATHWAYS ; PREVENTS
WOS Research AreaAnatomy & Morphology ; Neurosciences & Neurology
WOS SubjectAnatomy & Morphology ; Neurosciences
WOS IDWOS:000592155600001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/33516
Collection中国科学院心理健康重点实验室
Corresponding AuthorHu, Li
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
4.Guangzhou Med Univ, Dept Pain Management, State Key Clin Specialty Pain Med, Affiliated Hosp 2, Guangzhou, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Bi, Yanzhi,Wei, Zhaoxing,Kong, Yazhuo,et al. Supraspinal neural mechanisms of the analgesic effect produced by transcutaneous electrical nerve stimulation[J]. BRAIN STRUCTURE & FUNCTION,2020:12.
APA Bi, Yanzhi,Wei, Zhaoxing,Kong, Yazhuo,&Hu, Li.(2020).Supraspinal neural mechanisms of the analgesic effect produced by transcutaneous electrical nerve stimulation.BRAIN STRUCTURE & FUNCTION,12.
MLA Bi, Yanzhi,et al."Supraspinal neural mechanisms of the analgesic effect produced by transcutaneous electrical nerve stimulation".BRAIN STRUCTURE & FUNCTION (2020):12.
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