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Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia
Rollins, Colleen P. E.1; Garrison, Jane R.2; Arribas, Maite3,4; Seyedsalehi, Aida4,5; Li, Zhi6; Chan, Raymond C. K.6; Yang, Junwei7; Wang, Duo7; Lio, Pietro7; Yan, Chao8; Yi, Zheng-hui9; Cachia, Arnaud10,11; Upthegrove, Rachel12; Deakin, Bill13; Simons, Jon S.2; Murray, Graham K.5; Suckling, John1
First AuthorRollins, Colleen P. E.
Correspondent Emailcper2@cam.ac.uk (colleen p. e. rollins )
Contribution Rank6
Abstract

All perception is a construction of the brain from sensory input. Our first perceptions begin during gestation, making fetal brain development fundamental to how we experience a diverse world. Hallucinations are percepts without origin in physical reality that occur in health and disease. Despite longstanding research on the brain structures supporting hallucinations and on perinatal contributions to the pathophysiology of schizophrenia, what links these two distinct lines of research remains unclear. Sulcal patterns derived from structural magnetic resonance (MR) images can provide a proxy in adulthood for early brain development. We studied two independent datasets of patients with schizophrenia who underwent clinical assessment and 3T MR imaging from the United Kingdom and Shanghai, China (n=181 combined) and 63 healthy controls from Shanghai. Participants were stratified into those with (n=79 UK; n=22 Shanghai) and without (n=43 UK; n=37 Shanghai) hallucinations from the PANSS P3 scores for hallucinatory behaviour. We quantified the length, depth, and asymmetry indices of the paracingulate and superior temporal sulci (PCS, STS), which have previously been associated with hallucinations in schizophrenia, and constructed cortical folding covariance matrices organized by large-scale functional networks. In both ethnic groups, we demonstrated a significantly shorter left PCS in patients with hallucinations compared to those without, and to healthy controls. Reduced PCS length and STS depth corresponded to focal deviations in their geometry and to significantly increased covariance within and between areas of the salience and auditory networks. The discovery of neurodevelopmental alterations contributing to hallucinations establishes testable models for these enigmatic, sometimes highly distressing, perceptions and provides mechanistic insight into the pathological consequences of prenatal origins.

2020-11-06
Language英语
DOI10.1038/s41398-020-01075-y
Source PublicationTRANSLATIONAL PSYCHIATRY
ISSN2158-3188
Volume10Issue:1Pages:14
Subtype实证研究
Indexed BySCI
Funding ProjectGates Cambridge ; National Key Research and Development Program[2016YFC0906402] ; National Science Fund China[81571317] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; MRC Clinical Research Infrastructure Award[MR/M009041/1] ; NIHR Cambridge Biomedical Research Centre
PublisherSPRINGERNATURE
WOS KeywordANTERIOR CINGULATE CORTEX ; AUDITORY HALLUCINATIONS ; STRUCTURAL COVARIANCE ; PARACINGULATE SULCUS ; BRAIN ; REALITY ; GYRIFICATION ; ASYMMETRY ; RISK ; ABNORMALITIES
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000591309300008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/33525
Collection中国科学院心理健康重点实验室
Corresponding AuthorRollins, Colleen P. E.
Affiliation1.Univ Cambridge, Dept Psychiat, Cambridge, England
2.Univ Cambridge, Dept Psychol, Cambridge, England
3.Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge, England
4.Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England
5.Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England
6.Chinese Acad Sci, CAS Key Lab Mental Hlth, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
7.Univ Cambridge, Dept Comp Sci & Technol, Cambridge, England
8.East China Normal Univ, Key Lab Brain Funct Genom MOE & STCSM, Sch Psychol & Cognit Sci, Shanghai, Peoples R China
9.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China
10.Univ Paris, LaPsyDE, CNRS, F-75005 Paris, France
11.Univ Paris, IPNP, INSERM, F-75005 Paris, France
12.Univ Birmingham, Inst Mental Hlth, Birmingham, W Midlands, England
13.Univ Manchester, Neurosci & Psychiat Unit, Manchester, Lancs, England
Recommended Citation
GB/T 7714
Rollins, Colleen P. E.,Garrison, Jane R.,Arribas, Maite,et al. Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia[J]. TRANSLATIONAL PSYCHIATRY,2020,10(1):14.
APA Rollins, Colleen P. E..,Garrison, Jane R..,Arribas, Maite.,Seyedsalehi, Aida.,Li, Zhi.,...&Suckling, John.(2020).Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia.TRANSLATIONAL PSYCHIATRY,10(1),14.
MLA Rollins, Colleen P. E.,et al."Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia".TRANSLATIONAL PSYCHIATRY 10.1(2020):14.
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